Effect of Molecular Weight of Poly(Ethylene Glycol) Dicarboxylate on the Properties of Cross-Linked Hydrogel Film as an Antiadhesion Barrier

Q2 Materials Science

Polymer-Plastics Technology and Engineering Pub Date : 2018-09-22 DOI:10.1080/03602559.2017.1381254

Haryanto, N. Nurulita, E. Sundhani, P. Huh, S. Kim

引用次数: 1

Abstract

ABSTRACT Poly(ethylene glycol) dicarboxylate (PEGDC)/poly(ethylene oxide) (PEO) cross-linked hydrogel films were developed as an antiadhesion barrier using an e-beam. The effects of molecular weight of PEGDC on hydrogel properties were investigated. The decrease in molecular weight of PEGDC increased the gel fraction and tissue adhesion, whereas the mechanical strength did not change considerably. On the other hand, the swelling ratio decreased rapidly with decreasing molecular weight of PEGDC. The cytotoxicity of PEGDC (2000 or 3000) was low, whereas that of PEGDC (1000) was higher. In animal studies, all hydrogels showed a better antiadhesive effect compared to the control. GRAPHICAL ABSTRACT

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聚乙二醇二羧酸酯分子量对交联水凝胶膜抗粘附性能的影响

摘要:利用电子束制备了聚乙二醇二羧酸酯(PEGDC)/聚环氧乙烷(PEO)交联水凝胶膜作为抗粘附屏障。研究了PEGDC分子量对水凝胶性能的影响。PEGDC分子量的降低增加了凝胶分数和组织粘附性，而机械强度没有明显变化。另一方面，随着PEGDC分子量的减小，溶胀率迅速降低。PEGDC(2000和3000)的细胞毒性较低，而PEGDC(1000)的细胞毒性较高。在动物实验中，与对照组相比，所有水凝胶都表现出更好的抗粘附效果。图形抽象

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