001 UVA‐1 for the treatment of chronic hand dermatitis

B. Bergamo, C. Elmets
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Abstract

UVA-1 has distinct immunological effects which has allowed it to be useful for a number of cutaneous diseases that have been relatively resistant to other treatment modalities. These include urticaria pigmentosa, morphea/scleroderma and T-cell mediated diseases such as atopic dermatitis and cutaneous T-cell lymphoma. Since chronic hand dermatitis is also mediated by T-cells, we hypothesized that UVA- 1 would be an effective treatment for that disease as well. Five subjects with recalcitrant hand dermatitis caused by dyshidrosis and/or chronic irritancy were treated with a medium dose regimen of UVA- 1. This consisted of 15 treatments of 60 J/cm2 UVA 1 over 3 weeks. Subjects received a total of 900 J/cm2. A clinical scoring parameter, Dyshidrotic Area and Seventy Index Score (DASI), was administered to subjects prior to and following the UVA- 1 treatment course. Clinical photographs were also taken. All subjects showed improvement in hand dermatitis as demonstrated by clinical photographs and the DASI score (13 ± 5.35 before treatment; 6.3 ± 4.50 after treatment). UVA- 1 is an effective and rapid acting treatment for chronic hand dermatitis.
UVA‐1用于治疗慢性手部皮炎
UVA-1具有独特的免疫效果,这使得它对许多对其他治疗方式相对有抵抗力的皮肤疾病有用。这些疾病包括荨麻疹色素沉着症、硬皮病和t细胞介导的疾病,如特应性皮炎和皮肤t细胞淋巴瘤。由于慢性手部皮炎也是由t细胞介导的,我们假设UVA- 1也是一种有效的治疗方法。5例由汗湿和/或慢性刺激引起的顽固性手皮炎患者采用中剂量UVA- 1治疗。这包括15个60 J/cm2的UVA 1处理,持续3周。受试者共接受900 J/cm2。在UVA- 1疗程之前和之后,对受试者进行临床评分参数,即汗湿面积和70指数评分(DASI)。还拍摄了临床照片。临床照片和治疗前DASI评分(13±5.35)显示,所有受试者手部皮炎均有改善;治疗后6.3±4.50)。UVA- 1是一种快速有效的治疗慢性手部皮炎的药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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