ASSESSMENT OF CARCINOGENIC RISK FROM EXPOSURE TO CHEMICALS FROM FOOD PRODUCTS BASED ON REGIONAL EXPOSURE FACTORS

Abstract

BACKGROUND. At present, a lot of data has been accumulated indicating the risks of developing various toxic effects caused by exposure to chemicals that enter the human body with contaminated food. AIM. Evaluation of the carcinogenic risk to the health of the population of the Republic of Tatarstan associated with chemical contamination of food products based on regional exposure factors. METHODS. To assess the risk, the results of studies of food raw materials and food products for the period 2006-2019, carried out by the testing laboratory center of the FBUZ "Center for Hygiene and Epidemiology in the Republic of Tatarstan (Tatarstan)" were used. Calculations were made for the following groups of food raw materials and foodstuffs: meat and meat products; fish and fish products; milk and dairy products; bread and bakery products; sugar and confectionery; vegetables and melons (excluding potatoes); potato; fruits and berries; vegetable oils; eggs. RESULTS. As a result of the hazard identification, it was found that the following substances contained in food are of priority for the subsequent assessment of carcinogenic risk: hexachlorane, alpha-lindane, beta-lindane, lindane, heptachlor, cypermethrin, dichlorodiphenyltrichloroethane (DDT) and its metabolites, benzo(a) pyrene, derivatives of 2,4-dichlorophenoxyacetic acid (2,4-D), arsenic, cadmium, lead. It has been established that the total carcinogenic risk from exposure to the studied chemicals that contaminate food products ranges from alarming (7.9 10-4) to high (2.2 10-3 - 1.9 10-2) for various exposure schemes . CONCLUSION. The total carcinogenic risk is formed mainly as a result of contamination with pesticides: heptachlor, -lindane, -lindane, lindane and arsenic, which come mainly from vegetables, bread and bakery products, milk and dairy products.