Trained Immunity and Susceptibility to HIV

Q2 Biochemistry, Genetics and Molecular Biology

Clinical and Vaccine Immunology Pub Date : 2016-11-09 DOI:10.1128/CVI.00509-16

S. Derrick

引用次数: 5

Abstract

ABSTRACT In this issue of Clinical and Vaccine Immunology, K. Jensen et al. (Clin Vaccine Immunol 24:e00360-16, 2017, https://doi.org/10.1128/CVI.00360-16 ) describe a dual-purpose attenuated Mycobacterium tuberculosis-simian immunodeficiency virus vaccine (AMTB-SIV). Interestingly, immunized infant macaques required fewer oral exposures to SIV to become infected relative to nonimmunized animals. The authors hypothesized that augmented susceptibility to SIV was due to activation of CD4+ T cells through trained immunity. This commentary explores the possible relationship between trained immunity, enhanced CD4 T cell responses, and increased susceptibility to human immunodeficiency virus (HIV).

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训练有素的免疫力和对艾滋病毒的易感性

在这一期的《临床与疫苗免疫学》上，K. Jensen等人(临床疫苗免疫1 24:e00360-16, 2017, https://doi.org/10.1128/CVI.00360-16)描述了一种双重用途的减毒结核分枝杆菌-猴免疫缺陷病毒疫苗(AMTB-SIV)。有趣的是，与未接种疫苗的动物相比，接种疫苗的猕猴幼崽需要较少的SIV口服暴露才会被感染。作者假设对SIV的易感性增强是由于通过训练免疫激活CD4+ T细胞。这篇评论探讨了训练免疫、增强CD4 T细胞反应和增加对人类免疫缺陷病毒(HIV)易感性之间可能的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Vaccine Immunology 医学-传染病学

CiteScore

2.88

自引率

0.00%

发文量

审稿时长

1.5 months

期刊介绍： Cessation. First launched as Clinical and Diagnostic Laboratory Immunology (CDLI) in 1994, CVI published articles that enhanced the understanding of the immune response in health and disease and after vaccination by showcasing discoveries in clinical, laboratory, and vaccine immunology. CVI was committed to advancing all aspects of vaccine research and immunization, including discovery of new vaccine antigens and vaccine design, development and evaluation of vaccines in animal models and in humans, characterization of immune responses and mechanisms of vaccine action, controlled challenge studies to assess vaccine efficacy, study of vaccine vectors, adjuvants, and immunomodulators, immune correlates of protection, and clinical trials.