A new mixed-ligand Mn(II) coordination polymer: Protective and nursing values on renal calculus via reducing the Ca2+ concentration in urine

IF 2.1 4区化学 Q3 CHEMISTRY, PHYSICAL

Progress in Reaction Kinetics and Mechanism Pub Date : 2022-01-01 DOI:10.1177/14686783221090373

Yan Yang, Shenmin Zhang, Yi-Qian Zhang, Liang Chen, Tao Xiong

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Abstract

In the present study, via using the mixed-ligand synthesis approach, a new Mn(II)-containing coordination polymer (CP) with the chemical formula of {[Mn3(timb)2(SO3–IPA)2(H2O)2]·8H2O} n (1) has been successfully prepared via reaction of MnCl2·4H2O with the tripodal linker 1,3,5-tris(2-methylimidazole-1-yl)benzene (timb) and aromatic dicarboxylic acid ligand –SO3 group functionalized isophthalic acid (H2IPA) ligand. Furthermore, the biological activity of the new compound on renal calculus was assessed, and the related mechanism was explored as well. The Calcium Colorimetric Assay was conducted and the concentration of Ca2+ in urine was determined. The western blotting assay was conducted and the expression levels of the osteopontin (OPN) in the distal tubule were measured. Molecular docking simulation revealed that the carboxyl, iminazole, and sulfonate groups were all involving into the binding interactions with the target protein, and therefore exhibited strong biological activity.

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一种新型混合配体Mn(II)配位聚合物:通过降低尿中Ca2+浓度对肾结石的保护和护理价值

本研究采用混合配体合成方法，通过MnCl2·4H2O与三脚连接剂1,3,5-三(2-甲基咪唑-1-基)苯(timb)和芳香二羧酸配体-SO3基团功能化的异苯二甲酸(H2IPA)配体反应，成功制备了化学式为{[Mn3(timb)2(SO3-IPA)2(H2O)2]·8H2O} n(1)的新型含Mn(II)配位聚合物(CP)。进一步评价了该化合物对肾结石的生物活性，并对其作用机制进行了探讨。采用钙比色法测定尿中钙离子浓度。western blot检测大鼠远端小管骨桥蛋白(OPN)表达水平。分子对接模拟结果显示，羧基、咪唑基和磺酸基均参与了与靶蛋白的结合相互作用，因此具有较强的生物活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Progress in Reaction Kinetics and Mechanism 化学-物理化学

CiteScore

2.10

自引率

0.00%

发文量

审稿时长

2.3 months

期刊介绍： The journal covers the fields of kinetics and mechanisms of chemical processes in the gas phase and solution of both simple and complex systems.