Comparison between plasma lactate and lactate clearance with the impact of acute phase complication in burn injury patient

Abstract

Severe burn can cause rapid loss of intravascular volume with resultant a decrease in peripheral blood flow which reduces tissue oxygen transport and in turn, increases plasma lactate. Plasma lactate and lactate clearance are useful parameters to compare complicated and uncomplicated burn patients in the acute phase. The study aimed to evaluate the initial and 24-h plasma lactate levels as well as lactate clearance as useful parameters to assess acute phase complications of burn patients. This was a cross-sectional study involving 35 burn patients who admitted at Abdul Wahab Sjahranie District Hospital, Samarinda during the period of September 2018 to September 2019. The study was immediately begun after admission of the patients. Plasma lactate levels were measured at admission and24-h after the first measurement. The acute phase complication was assessed 72 h after burns from the laboratory parameter. Fisher’s exact test and t test using SPSS software version 24were applied for statistical analysis. The 24-h plasma lactate level (p= 0.001) and plasma lactate clearance (p = 0.002) were significantly correlated with the occurrence of acute phase complications of burns. However, the initial plasma lactate level was not significantly correlated (p = 0.609). In conclusion, there is a significantly correlation between 24-h plasma lactate level and plasma lactate clearance are with the occurrence of acute phase complications of burns.