Synthesis and characterization of some new tebufenozide analogues and study their toxicological effect against Spodoptera littoralis (Boisd.)

Q2 Chemistry

Current Chemistry Letters Pub Date : 2022-01-01 DOI:10.5267/j.ccl.2021.9.005

O. Elhady, Erian. S. Mansour, M. Elwassimy, Sameh A. Zawam, A. Drar

引用次数: 4

Abstract

Many of mimic analogues synthesized before depending on the change in the structure of aromatic rings. In this work, the carbonyl group in the structure of compounds 1-4 converted to thiocarbonyl group, and then studying the toxicological activity due to chemical change in the active center of mimic analogues was performed for compounds N-tert-butyl-2,4-dichloro-N'-(2,4-dichlorobenzoyl)benzohydrazide (2) and N-tert-butyl-2,4-dichloro-N'-[(2,4-dichlorophenyl)carbonothioyl]benzenecarbothiohydrazide (6). The toxicological study was done by using 2nd and 4th instar larvae of the cotton leaf worm, Spodoptera littoralis (Boisd.). Five concentration levels (600, 300, 150, 75 and 37.5 ppm) of compounds (2) and (6) were applied on the fresh plant food to the newly grown (2nd and 4th) instar larvae.

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几种新型虫酰肼类似物的合成、表征及对沿海夜蛾的毒理学效应研究

许多模拟类似物的合成依赖于芳香环结构的变化。在这部作品中,羰基化合物1 - 4的结构转换成thiocarbonyl组,然后研究毒理学活动由于化学变化模拟类似物的活性中心进行化合物N-tert-butyl-2 4-dichloro-N ' - (2, 4-dichlorobenzoyl) benzohydrazide(2)和N-tert-butyl-2 4-dichloro-N”- - - - - - [(2,4-dichlorophenyl) carbonothioyl] benzenecarbothiohydrazide(6)。所做的毒理学研究是使用2日和4日龄幼虫的棉叶虫,沿海夜蛾(Boisd.)用600、300、150、75和37.5 ppm 5个浓度水平的化合物(2)和(6)分别施用于新鲜植物食物上，对新生的(2龄和4龄)幼虫进行处理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Chemistry Letters Chemistry-Chemistry (all)

CiteScore

4.90

自引率

0.00%

发文量

审稿时长

20 weeks

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