Lactoferrin Nanoparticles as Therapeutic Agent for Infectious Diseases

Journal of Dairy Science and Technology Pub Date : 2019-03-16 DOI:10.37591/RRJODST.V7I3.1824

Prashant Agarwal, Ritika Gupta

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引用次数: 1

Abstract

Lactoferrin (Lf) is a mammalian cationic iron-binding glycoprotein, present in many mammalian excretions and supporting newborn growth to food and pharmaceutical applications. It possesses antibacterial, antimicrobial, antiviral and antiparasitic activity thus, making it an important part of the host defense system. This review focusses on recent therapeutic advances of the natural bioactive protein Lf and its use as a potential treatment agent. Nanoparticles have been tremendously used for several clinical applications preferably as drug delivery system to improve the therapeutic efficacy. Effective conjugation of functionalized agents can improve the binding affinity of nanoparticles to specific areas of the body. Therefore, this property can ensure the protection of bioactive molecules from degradation and enabled prolonged sustainability without severe side-effects. In this study, significant advancements in Lf nanoparticle technology and their use in drug delivery arena have also been reviewed. Keywords: Lactoferrin, nanoparticles, drug delivery, therapeutic Cite this Article Prashant Agarwal, Ritika Gupta. Lactoferrin Nanoparticles as Therapeutic Agent for Infectious Diseases. Research and Reviews: Journal of Dairy Science and Technology . 2019; 7(3): 37–40p.

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乳铁蛋白纳米颗粒作为感染性疾病的治疗剂

乳铁蛋白(Lf)是一种哺乳动物阳离子铁结合糖蛋白，存在于许多哺乳动物的排泄物中，并支持新生儿的生长，用于食品和制药。它具有抗菌、抗微生物、抗病毒和抗寄生虫的活性，是宿主防御系统的重要组成部分。本文综述了近年来天然生物活性蛋白Lf的治疗进展及其作为潜在治疗剂的应用。纳米颗粒已广泛应用于多种临床应用，特别是作为药物传递系统，以提高治疗效果。功能化剂的有效偶联可以提高纳米颗粒对身体特定区域的结合亲和力。因此，这种特性可以确保生物活性分子免受降解的保护，并在没有严重副作用的情况下实现长期可持续性。在本研究中，本文还综述了Lf纳米颗粒技术及其在给药领域的重大进展。关键词:乳铁蛋白，纳米颗粒，药物传递，治疗性乳铁蛋白纳米颗粒作为感染性疾病的治疗剂。研究与评述:乳品科学与技术杂志。2019;7 (3): 37-40p。

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Journal of Dairy Science and Technology

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