Lycopene in tomato as nephrotoxic and anti-inflammatory in welding workers exposed to cadmium

Abstract

Objective: The aim of this study were to know the effect of administration tomato powder as anti nephrotoxic and anti inflammatory on welding workers exposed by Cd. Methods: This research use observational analytical with cross -sectional design. Research subject consisted of 30 welding workers in Purwokerto aged 25-55 years with a work period more than 3 years. Welding workers were given tomato powder at 14 packs at a dose of 30 g for consumption for 14 days. On the 0 th and 15 th day, blood was taken to examine kidney function and inflammatory parameters. These data analyzed by paired t-test. Results: The results showed blood Cd levels, Creatinine, β2-microglobuline,Tumor Necrosis Factor-α and Cyclooxygenase-2 levels after being given tomato powder were very significant difference compare to before given tomatoes. Conclusions: It can be concluded that the administration of tomato powder has an effect on improving kidney function. Tomatoes powder decrease in both blood Cd levels and proinflammatory cytokines in welding workers exposed by Cd.