Comparative Study of Interleukin 28B Gene in Genotype 3 Chronic Hepatitis C Patients Before and After Treated With Interferon/Pegylated in Sindh

SINDH UNIVERSITY RESEARCH JOURNAL -SCIENCE SERIES Pub Date : 2019-06-19 DOI:10.26692/SUJO/2019.6.49

S. Qureshi, A. Ghanghro, M. S. Memon, N. Shaikh, A. M. Waryah

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Abstract

Chronic hepatitis C (HCV) caused by hepatitis C (HCV) virus, approximately estimated 170-200 million individuals in the world including Pakistan having 10 million HCV infected . The effective available treatment option is a combination of Pegylated interferon (PegIFN) and Ribavirin (RBV) . Recently Genome wide association studies (GAWAS)supporting two single nucleotide polymorphism SNPs adjacent interleukin 28B gene associated with spontaneous and treatment induced clearance of HCV patients. The aim of the present study was to analysis the impact of response associated interleukin 28B(IL28B) single nucleotide polymorphism (SNPs) rs12979860, rs8099917 in different treatment interval with one month (RVR) and after end of treatment (SVR) with Pegylated Interferon(PEG IFN) and Ribavirin in Hepatitis C genotype 3 patients. The present study enrolled 200 HCV RNA positive genotype 3 patients having both SNPs (rs12979860, rs8099917) were analyzed by Real Time Polymerase Chain Reaction (RT-PCR). The frequency distribution of IL28B genotypes were investigated by SNIPs (rs12979860 and rs8099917) in HCV RNA positive genotype 3 patients in Pakistani population

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干扰素/聚乙二醇化治疗信德省基因3型慢性丙型肝炎患者前后白细胞介素28B基因的比较研究

由丙型肝炎(HCV)病毒引起的慢性丙型肝炎(HCV)，世界上估计约有1.7 -2亿人，包括巴基斯坦有1000万HCV感染者。有效的可用治疗方案是聚乙二醇化干扰素(PegIFN)和利巴韦林(RBV)的联合治疗。最近的全基因组关联研究(GAWAS)支持两个单核苷酸多态性SNPs邻近的白介素28B基因与HCV患者自发和治疗诱导的清除相关。本研究的目的是分析与白细胞介素28B(IL28B)单核苷酸多态性rs12979860、rs8099917在聚乙二醇化干扰素(PEG IFN)和利巴韦林治疗1个月(RVR)和治疗结束(SVR)后不同治疗间隔(RVR)的影响。采用实时聚合酶链式反应(RT-PCR)对200例具有rs12979860和rs8099917两个snp的HCV RNA基因3型阳性患者进行分析。采用SNIPs (rs12979860和rs8099917)检测巴基斯坦人群HCV RNA基因3阳性患者IL28B基因型的频率分布

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SINDH UNIVERSITY RESEARCH JOURNAL -SCIENCE SERIES

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