Association of Serum Uric Acid and Parkinson’s Disease: A Case Control Study

Bangladesh Journal of Neuroscience Pub Date : 2015-01-31 DOI:10.3329/bjn.v31i1.57377

Md Enayet Ul Islam, Aminur Rahman, Farhan Salam, Takib Uddin Ahmed, U. K. Saha, Z. Ali, Sakhawat Hossain, Md. Rafiqul Islam

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Abstract

Aim: Recent studies have provided evidence that uric acid (UA) is supposed to play a neuro-protective role in Parkinson’s disease (PD). Uric acid is a natural antioxidant that may reduce oxidative stress, a mechanism thought to play a role in the pathogenesis of PD. This study aimed to evaluate whether the serum UA level was associated with PD in a relatively small population of Bangladeshi patients. Materials and methods: An observational prospective case control Study was conducted in Neurology department of Sir Salimullah Medical College & Mitford Hospital including both the male and female wards during July 2012 to December 2013. Serum uric acid were determined from 40 PD patients and compared with 70 age and sex matched control; following the uric acid colorimetric method, the serum creatinine (Scr) levels were also measured to reduce the bias caused by possible differences in renal excretion function. Data were analyzed with software SPSS 16 and statistical descriptive methods (mean percentage, SD) and t-test. Result: In this study, 22 men (55%) and 18 women (45%) with PD were evaluated. The mean serum uric acid in patients was 3.7±0.97 and in the control group was 5.32 ±0.44. This difference was statistically significant.(p=0.001) Also, the mean serum uric acid in both men (3.48±0.98) and women (4.1±1.17) patients group was statistically lower than both men (5.39±0.46) and women (5.17±0.35) in control group.(p=0.001). Conclusion: This present study showed a positive association between low serum UA and PD . Bangladesh Journal of Neuroscience 2015; Vol. 31 (1): 9-14

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血清尿酸与帕金森病的关系:一项病例对照研究

目的:最近的研究提供了尿酸(UA)在帕金森病(PD)中发挥神经保护作用的证据。尿酸是一种天然抗氧化剂，可以减少氧化应激，这一机制被认为在帕金森病的发病机制中起作用。本研究旨在评估在相对较小的孟加拉国患者群体中血清UA水平是否与PD相关。材料与方法:2012年7月至2013年12月，在Sir Salimullah Medical College & Mitford Hospital神经内科男、女病区进行观察性前瞻性病例对照研究。测定40例帕金森病患者的血清尿酸，并与70例年龄和性别匹配的对照组进行比较;在尿酸比色法之后，还测量了血清肌酐(Scr)水平，以减少肾脏排泄功能可能差异引起的偏差。数据分析采用SPSS 16软件，采用统计描述性方法(平均百分比、SD)和t检验。结果:本研究共对22例男性PD患者(55%)和18例女性PD患者(45%)进行了评估。患者血清尿酸均值为3.7±0.97，对照组为5.32±0.44。患者组男性(3.48±0.98)、女性(4.1±1.17)的血清尿酸均值均低于对照组男性(5.39±0.46)、女性(5.17±0.35)，差异有统计学意义(p=0.001)。结论:本研究显示低UA与PD呈正相关。孟加拉国神经科学杂志2015;Vol. 31 (1): 9-14

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Bangladesh Journal of Neuroscience

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