Effect of Omega-3 Polyunsaturated Fatty Acid on the Prevention of Atrial Fibrillation after Off-Pump Coronary Artery Bypass Grafting

University Heart Journal Pub Date : 2022-01-31 DOI:10.3329/uhj.v18i1.57878

Akm Rakibuzzaman, F. Sazzad, M. Wadud, Md Abdul Gafur, S. Islam, Israt Jahan, Md Azizul Islam Khan, Rampada Sarker

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Abstract

Background: Postoperative atrial fibrillation (POAF) often occurs in patients after coronary artery bypass graft surgery (CABG), both conventional and off pump ranges from 11% to 40%. Although often transient, self-limited, and benign, it may be associated with increased postoperative morbidity. The prevention of POAF has been associated with improved postoperative outcomes in terms of reduced medical treatment, laboratory tests, shorter nursing time, and hospital stay, even when uncomplicated. The present study was conducted to find out the effect of omega polyunsaturated fatty acid on the prevention of POAF after off pump CABG. Method: This cross-sectional study was conducted in the Department of Cardiac Surgery, National Institute of Cardiovascular Diseases (NICVD), Sher-E-Bangla Nagar, Dhaka, between September 2017 and August 2018. Total 100 patients with sinus rhythm admitted for OPCAB were included in this study, and they were divided into two groups, Group A, 50 patients having omega-3 PUFA in the preoperative and postoperative period up to the fifth postoperative day (POD) and Group B, 50 patients not having omega-3 PUFA in the preoperative and postoperative period up to the fifth POD. Findings were compared between two groups preoperatively, postoperatively, up to 5 days, at discharge, and at one month after discharge. Results: Postoperative AF was significantly higher in group B in comparison to group A up to 5th POD. AF was present in a few patients during discharge and one month after discharge, but the differences were statistically not significant between groups. Total ICU stay was similar between the two groups, but the postoperative hospital stay was shorter in Group A, and the mean difference was statistically significant. Conclusion: This study concluded that perioperative oral omega-3 polyunsaturated fatty acid intake reduces the incidence of postoperative atrial fibrillation in patients undergoing off pump coronary artery bypass graft surgery. University Heart Journal 2022; 18(1): 36-43

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Omega-3多不饱和脂肪酸对非体外循环冠状动脉搭桥术后房颤的预防作用

背景:术后心房颤动(POAF)经常发生在冠状动脉搭桥手术(CABG)后的患者中，无论是常规的还是无泵的范围都在11%到40%之间。虽然通常是短暂的、自限性的和良性的，但它可能与术后发病率增加有关。在减少医疗、实验室检查、缩短护理时间和住院时间方面，预防POAF与改善术后结果相关，即使在不复杂的情况下也是如此。本研究旨在探讨omega多不饱和脂肪酸对停泵冠脉搭桥后POAF的预防作用。方法:本横断面研究于2017年9月至2018年8月在达卡Sher-E-Bangla Nagar国家心血管疾病研究所(NICVD)心脏外科进行。本研究共纳入100例因OPCAB入院的窦性心律患者，将其分为两组，A组50例术前术后至术后第5天(POD)服用omega-3 PUFA的患者，B组50例术前术后至第5天(POD)未服用omega-3 PUFA的患者。比较两组术前、术后、出院前5天、出院时和出院后1个月的结果。结果:术后至第5 POD时，B组AF明显高于A组。少数患者在出院时和出院后1个月出现房颤，但组间差异无统计学意义。两组患者ICU总住院时间相似，但A组患者术后住院时间更短，平均差异有统计学意义。结论:本研究认为围手术期口服omega-3多不饱和脂肪酸可降低非体外循环冠状动脉搭桥术患者术后房颤的发生率。大学心脏杂志2022;18(1):第36 -

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University Heart Journal

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