Novel polymer vectors of 64Cu

Abstract

Abstract We describe a preparation of novel polymer vectors of 64Cu based on co-polymers of poly- (N-isopropylacrylamide) and poly- (N-hydroxypropylmethacrylamide). DOTA, DTPA, dipicolylamine, thiosemicarbazone and Ag-ionophore-II ligands were tested to bind 64Cu in a polymer chain. Labeling yields with no-carrier-added 64Cu varied from 95 to 99% in 30 min. at laboratory temperature. Vectors were stable in vitro for 24 h in human serum and might be prospective for targeted 64Cu radio or combined radiochemotherapy.