Aegle Marmoles Biosynthesized Silver Nanoparticle Loaded Hydrogel for Topical Application for Wound Dressing

Abstract

Nanotechnology gain significance importance in various field such as medicine, electronic, waste treatment and defence sectors. The physical, chemical and biological methods of producing and usage of nanoparticles for different end economic cost of beneficial application brought wide interest on nanoparticles. Aegle marmelos commonly known as Bael is used in ancient Indian medicine siddha and Ayurveda from time immemorial. It also considered to be most sacred plant in India. Silver Nanoparticles were synthesized with the aid of novel, non-toxic, eco-friendly biological method using Aegle marmelos leaf extract. Silver nanoparticles used in medicinal industry such as topical ointment to prevent infection against burns and wounds. Hydrogel loaded with metal nanoparticle have great importance for many applications in the biomedical and biotechnological field. In the present study, the biosynthesis of silver nanoparticles-based hydrogel of Maha vilvam (Aegle marmelos) extract for topical delivery. The usage of Aegle marmelos in the form of hydrogel with nanoparticle has extended its well-established application in the field of wound healing, tissue engineering and drug delivery. Further, the characterization study was carried out on biosynthesised silver nanoparticle loaded hydrogel by using UV-Visible spectrophotometer, Fourier Transform –Infrared Spectroscopy and SEM analysis. The antimicrobial resistance was accessed for the biosynthesised silver nanoparticle loaded hydrogel against Escherichia coli and Staphylococcus aureus, zone of inhibition was measured.