Formulation, Standardization and Physiochemical evaluation of Novel Siddha Preparation Naga Chendurum as per AYUSH guideline

Abstract

Siddha formulations offer atremendous advantage in clinical practice against metabolic and lifestyle disorders including neurodegenerative diseases. Often investigation on Siddha preparations attempted on reverse pharmacology basis. Hence nearly 80% of the formulation already have proven track record clinically and now several investigationsare being made on its preclinical aspect. Considering the global need the modern standardization method adopted for identity, purity and shelf life of the preparation. Different techniques have been followed to analyze the purity of the raw materials it includes a microscopic, macroscopic, Physical, chemical and biological method of analysis. Physicochemical evaluation of the preparation plays a vital role in establishing the monograph of the formulation, as it becomes the documentary evidence to substantiate the standards of the preparation. It renders the useful information like genuinity, stability, selective characteristic feature and nature of the compound’s presence in the drug. WHO and other regulatory authorities in collaboration with government agency setup a benchmark for proper standardization of the raw drug as well the finished formulations. According to these guidelines parameters such as loss on drying, Total ash, Extractive value and pH provides some important details on identifying the stability and genuinity of the drugs as well. The main aim of the present investigation is to standardize the novel formulation Naga Chendurum (NC) as per AYUSH guideline and to reveal the property of the formulation to the scientific community for better understanding about the standards of the formulation. The results obtained from the physicochemical evaluation revealsthattotal ash value of NCwas found to 92.38%. In which the water-soluble ash was 33.51% and acid insoluble ash was 46 %. Similarly, loss on drying value at 105C was found to be 0% respectively. pH is an important indicator for the solvent solubility and ability to cross the biological barrier. pH of the formulation NC was found to be 6.77.From the results of the study, it was evident that the Siddha formulation NC complies with the standard and may be used for clinical management of Vathadiseases, Kasam, Vallikunmam, Erikunmam etc. But further studies need to be carried out to ascertain the exact role of phytotherapeutics present in the formulation might responsible for the expected pharmacological action in humans and animals as well.