Clinico-laboratory profile of scrub typhus from mid and lower Himalayan region in north India

Pediatric Infectious Disease Pub Date : 2015-07-01 DOI:10.1016/j.pid.2015.11.003

Sandesh Guleria , Jyoti Sharma , Sanjeev Chaudhury , Pankaj Kumar

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引用次数: 3

Abstract

Aim

To describe the clinico-laboratory profile of scrub typhus diagnosed in a tertiary care institution in northern India.

Materials and methods

All cases of febrile illness diagnosed as scrub typhus over a period of 6 months were analyzed retrospectively. Diagnosis was based on positive IgM ELISA.

Results

Forty-four cases of scrub typhus were seen over a period of 6 months (July 2013 and December 2013). Common clinical features were fever (100%), lymphadenopathy (68.18%), hepatomegaly (56.82%), splenomegaly (47.73%), vomiting (38.64%), signs of meningeal irritation (38.64%), abdominal pain (31.82%), hypotension (31.82%), pedal edema (29.54%), rash (20.45%), and cough (11.36%). Eschar was seen in 10 (22.73%) cases. Common laboratory findings were thrombocytopenia (68.18%), increased liver enzymes (40.9%), meningitis (34.1%), leucocytosis (34.1%), and azotemia (22.73%). Multiple organ dysfunction syndrome (MODS) was present in 24 (54.54%) patients, shock in 15 (34.1%), meningitis in 15 (34.1%), ARDS in 11 (25%), hepatitis in 11 (25%), and azotemia in 10 (22.73%) patients. A total of 3 (6.82%) patients died.

Conclusion

Scrub typhus has emerged as an important cause of febrile illness with multisystemic involvement and high rate of MODS.

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印度北部喜马拉雅中下游地区恙虫病的临床-实验室分析

目的描述在印度北部三级保健机构诊断的恙虫病的临床-实验室概况。材料与方法回顾性分析我院近6个月确诊为恙虫病的发热病例。诊断基于IgM ELISA阳性。结果2013年7月至2013年12月共发现恙虫病44例。常见临床特征为发热(100%)、淋巴结病(68.18%)、肝肿大(56.82%)、脾肿大(47.73%)、呕吐(38.64%)、脑膜刺激(38.64%)、腹痛(31.82%)、低血压(31.82%)、足部水肿(29.54%)、皮疹(20.45%)、咳嗽(11.36%)。结痂10例(22.73%)。常见的实验室结果是血小板减少(68.18%)、肝酶升高(40.9%)、脑膜炎(34.1%)、白细胞增多(34.1%)和氮质血症(22.73%)。多器官功能障碍综合征(MODS) 24例(54.54%)，休克15例(34.1%)，脑膜炎15例(34.1%)，ARDS 11例(25%)，肝炎11例(25%)，氮血症10例(22.73%)。死亡3例(6.82%)。结论恙虫病是一种多系统受累、MODS发生率高的发热性疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Infectious Disease

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