Spirooxindoles, a potential novel class of anti-inflammatory agents

Jia Liu, Yulong Sun, Xuehong Zhang, Li Xiaolei, Yanjing Wu, Yiqing Wang, Xianxing Jiang
{"title":"Spirooxindoles, a potential novel class of anti-inflammatory agents","authors":"Jia Liu, Yulong Sun, Xuehong Zhang, Li Xiaolei, Yanjing Wu, Yiqing Wang, Xianxing Jiang","doi":"10.14800/ICS.372","DOIUrl":null,"url":null,"abstract":"In a previous study, we reported a class of spirooxindole-pyranopyrimidine compounds that exhibited broad spectrum anti-cancer activity. In a most recent study, we found that one of these compounds, JP-8g, also showed potent in vivo anti-inflammatory activity. In vitro and in vivo experiments suggested that JP-8g exerts this activity through nitric oxide (NO) signaling pathway. Herein, we discuss the potential of the use of these compounds as anti-inflammatory agents. The new data in this study also suggested that NF-kB signaling pathway is not involved in the anti-inflammatory activity of JP-8g.","PeriodicalId":13679,"journal":{"name":"Inflammation and cell signaling","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2014-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"7","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Inflammation and cell signaling","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14800/ICS.372","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 7

Abstract

In a previous study, we reported a class of spirooxindole-pyranopyrimidine compounds that exhibited broad spectrum anti-cancer activity. In a most recent study, we found that one of these compounds, JP-8g, also showed potent in vivo anti-inflammatory activity. In vitro and in vivo experiments suggested that JP-8g exerts this activity through nitric oxide (NO) signaling pathway. Herein, we discuss the potential of the use of these compounds as anti-inflammatory agents. The new data in this study also suggested that NF-kB signaling pathway is not involved in the anti-inflammatory activity of JP-8g.
螺旋体吲哚,一种潜在的新型抗炎剂
在之前的研究中,我们报道了一类具有广谱抗癌活性的吡喃嘧啶类化合物。在最近的一项研究中,我们发现其中一种化合物JP-8g也显示出有效的体内抗炎活性。体外和体内实验表明,JP-8g通过一氧化氮(NO)信号通路发挥这种活性。在此,我们讨论了使用这些化合物作为抗炎剂的潜力。本研究的新数据也提示NF-kB信号通路不参与JP-8g的抗炎活性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信