Multimodal Approach with CAR-T and CAR-NK Cells for Synergistic Action to Treat Cancer

Abstract

Recent years have seen a craze about the T-cell immunotherapy for B-cell malignancies, and there is growing interest in NK-CAR therapy. In this paper, I discuss the similarities and differences between the CARs in the NK and T-Cells. Further, explore the possible theoretical concept of a multimodal approach towards treating cancer. Whether the two genetically modified cells could provide an added advantage acting synergistically to complement each other’s therapeutic qualities or counteract each other’s downfall. This short communication is an attempt to pique interest to understand the mechanisms of NK cell and T cell biological interaction in the presence of a therapeutic weapon “CAR” to target tumor.