Structural changes of capsular, vascular, glial and neural elements of the spinal ganglia in acute experimental edema. Light and electron microscopic studies

Abstract

As a result of an increase in vascular permeability under the influence of intravenously administered endotoxin (LPS) in subcapsular, perivascular, perineuronal and interneuronalspaces of the spinal ganglia were identified unstained areas corresponding to theplacement of edematous fluid. Dimensions of the "perineural windows" formed in the inner layerspinal ganglion capsule depends on the number and perimeter (exchange surface area)vessels of the spinal ganglia. Disruption of the relationship between pseudo-unipolar neuronsand glial satellite cells leads to the formation of dark degenerative neurons.It was ultrastructurally proved that the cause of pyroptosis death of macrophages located insideIn the spinal ganglia, it is not the E. coli itself, but the LPS, which is part of its wall.