Herbal Moieties and its effect on Parkinsonism: A New Prospective

YMER Digital Pub Date : 2022-08-12 DOI:10.37896/ymer21.08/41
Arvind Kumar
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Abstract

Parkinson’s disease is a brain disease that leads to stiffness, shaking, and problems with walking, balance of coordination, and brain injury. It occurs when nerve cells or neurons that produce an important brain channel known as dopamine and control the movements in an area of the brain is impaired and die. Parkinson’s symptoms usually begin gradually and get worse over times. Age is the one clear risk factor for this disease. A person with Parkinson’s disease may have clumps of proteins known as alpha synuclein or Lewy bodies in their brain. There is no cure for Parkinson’s disease, the aim of medical management of Parkinson’s disease to restore the proper balance of dopaminergic and cholinergic activities in the brain in order to relieve symptoms. This review presents a brief overview of scientific basis that support the plant derived natural products and their constituents for the treatment of underlying neuronal degeneration observed in Parkinson’s disease. The neuroprotective effects exhibited by these medicinal plants and their constituents are considered to be due to their ability to modulate; glutathione, superoxide dismutase and catalase in the brain, which all are disrupted in the PD brain. Keywords: PD, Indian Herbs
草药成分及其对帕金森病的作用:一个新的前景
帕金森氏症是一种脑部疾病,会导致僵硬、颤抖、行走困难、协调平衡和脑损伤。当产生被称为多巴胺的重要大脑通道并控制大脑某个区域运动的神经细胞或神经元受损和死亡时,就会发生这种情况。帕金森氏症的症状通常是逐渐开始的,并随着时间的推移而恶化。年龄是这种疾病的一个明显的危险因素。帕金森氏症患者的大脑中可能有称为α突触核蛋白或路易小体的蛋白质团块。帕金森氏病目前还没有治愈的方法,医学管理帕金森氏病的目的是恢复大脑中多巴胺能和胆碱能活动的适当平衡,以缓解症状。这篇综述简要介绍了支持植物来源的天然产物及其成分治疗帕金森病中观察到的潜在神经元变性的科学基础。这些药用植物及其成分所表现出的神经保护作用被认为是由于它们的调节能力;大脑中的谷胱甘肽,超氧化物歧化酶和过氧化氢酶,这些都在PD大脑中被破坏。关键词:PD;印度草药
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