Biological Activity of Gold Compounds against Viruses and Parasitosis: A Systematic Review

BioChem Pub Date : 2022-05-14 DOI:10.3390/biochem2020010

Custódia S. C. Fonseca, M. Aureliano

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引用次数: 3

Abstract

In this contribution, we provide an overview of gold compound applications against viruses or parasites during recent years. The special properties of gold have been the subject of intense investigation in recent years, which has led to the development of its chemistry with the synthesis of new compounds and the study of its applicability in various areas such as catalysis, materials, nanotechnology and medicine. Herein, thirteen gold articles with applications in several viruses, such as hepatitis C virus (HCV), influenza A virus (H1N1), vesicular stomatitis virus (VSV), coronavirus (SARS-CoV and SARS-CoV-2), Dengue virus, and several parasites such as Plasmodium sp., Leishmania sp., Tripanossoma sp., Brugia sp., Schistosoma sp., Onchocerca sp., Acanthamoeba sp., and Trichomonas sp. are described. Gold compounds with anti-viral activity include gold nanoparticles with the ligands mercaptoundecanosulfonate, 1-octanethiol and aldoses and gold complexes with phosphine and carbene ligands. All of the gold compounds with anti-parasitic activity reported are gold complexes of the carbene type. Auranofin is a gold drug already used against rheumatoid arthritis, and it has also been tested against virus and parasites.

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金化合物抗病毒和寄生虫生物活性的系统综述

在这篇文章中，我们概述了近年来金化合物在抗病毒或寄生虫方面的应用。近年来，人们对金的特殊性质进行了深入的研究，在催化、材料、纳米技术和医学等领域对其应用的研究和新化合物的合成，促进了其化学的发展。本文介绍了在几种病毒(如丙型肝炎病毒(HCV)、甲型流感病毒(H1N1)、水疱性口炎病毒(VSV)、冠状病毒(SARS-CoV和SARS-CoV-2)、登革热病毒以及几种寄生虫(如疟原虫、利什曼原虫、Tripanossoma sp.、Brugia sp.、血吸虫sp.、盘尾丝虫sp.、棘阿米巴sp.和滴虫sp.)中的应用的13篇金文章。具有抗病毒活性的金化合物包括与巯基癸磺酸、1-辛烷硫醇和醛糖配体的金纳米颗粒以及与膦和碳烯配体的金配合物。报道的具有抗寄生活性的金化合物均为卡宾型金配合物。金嘌呤是一种黄金药物，已经被用于治疗类风湿性关节炎，它也被用于治疗病毒和寄生虫。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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BioChem

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