A mathematical model to describe antibody-dependent enhancement and assess the effect of limiting cloning for plasma cells in heterologous secondary dengue infection.

IF 0.8 4区 数学 Q4 BIOLOGY
Felipe Alves Rubio, Hyun Mo Yang
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引用次数: 2

Abstract

We propose a mathematical model to study the antibody-dependent enhancement (ADE) phenomenon. Here, we explore the interaction between macrophages, dengue virus and plasma cells, especially the effect of a limitation on plasma cell proliferation, which occurs due to immunological memory. The model has up to three equilibrium points: one virus-free equilibrium and two virus-presence equilibrium, depending on the value of two thresholds. We determine the existence regions for the model equilibrium points and their stability, a sensitivity analysis was performed in the model thresholds. Numerical simulations illustrate that ADE can occur even when the basic reproduction number is less than one.
一个数学模型来描述抗体依赖性增强和评估限制克隆对异源继发性登革热感染浆细胞的影响。
我们提出了一个数学模型来研究抗体依赖性增强(ADE)现象。在这里,我们探讨巨噬细胞、登革热病毒和浆细胞之间的相互作用,特别是免疫记忆对浆细胞增殖的限制的影响。根据两个阈值的值,该模型最多有三个平衡点:一个无病毒平衡点和两个病毒存在平衡点。我们确定了模型平衡点及其稳定性的存在区域,并对模型阈值进行了敏感性分析。数值模拟表明,即使基本繁殖数小于1,ADE也会发生。
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来源期刊
CiteScore
2.20
自引率
0.00%
发文量
15
审稿时长
>12 weeks
期刊介绍: Formerly the IMA Journal of Mathematics Applied in Medicine and Biology. Mathematical Medicine and Biology publishes original articles with a significant mathematical content addressing topics in medicine and biology. Papers exploiting modern developments in applied mathematics are particularly welcome. The biomedical relevance of mathematical models should be demonstrated clearly and validation by comparison against experiment is strongly encouraged. The journal welcomes contributions relevant to any area of the life sciences including: -biomechanics- biophysics- cell biology- developmental biology- ecology and the environment- epidemiology- immunology- infectious diseases- neuroscience- pharmacology- physiology- population biology
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