Investigation of genes coding for anti-HIV proteins MAP30 and MRK29 from Thai bitter melon (Momordica charantia L.)

Q4 Pharmacology, Toxicology and Pharmaceutics

Pharmaceutical Sciences Asia Pub Date : 2022-01-01 DOI:10.29090/psa.2022.01.21.104

Paktraporn Mekloy, K. Sakchaisri, W. Jiratchariyakul, S. Bunsupa

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Abstract

Momordica charantia L. (M. charantia), also known as bitter melon, belongs to the Cucurbitaceae family. M. charantia is cultivated in many regions globally, including Asia, South America, and Africa. It has many varieties and local names, including the Chinese variety (lai-pu-tao, ku-gua), Japanese variety (goya), Indian variety (karela), Vietnamese variety (la khoqua), and Thai variety (mara). Varieties differ substantially in the shape and bitterness of the fruit. However, they have the same scientific name as Momordica charantia L.. The plant has been widely used as herbal anti-aging medicine. Major pharmacological activities that have been observed in bitter melon include abortifacient, antidiabetic, antibacterial, antiviral, and antitumor. These characteristics have been correlated with the presence of phytochemicals, including saponins, alkaloids, triterpenes, steroids, and proteins. Several compounds have been isolated from all plant parts, such as momordicins, charantins, cucurbitins, and goyaglycosides. Charantins, a mixture of steroidal saponins found in the fruits of M. charantia exhibit hypoglycaemic activity. Many proteins and peptides which possess RNA N-glycosidase, DNase-like, antitumor, immunosuppressive, and antimicrobial activities have also been isolated, such as

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泰国苦瓜抗hiv蛋白MAP30和MRK29基因编码的研究

苦瓜(Momordica charantia L.， M. charantia)，又名苦瓜，属于葫芦科。夏兰草在全球许多地区都有种植，包括亚洲、南美和非洲。它有许多品种和地方名称，包括中国品种(lai-pu-tao, ku-gua)，日本品种(goya)，印度品种(karela)，越南品种(la khoqua)和泰国品种(mara)。不同的品种在形状和苦味上有很大的不同。然而，它们与Momordica charantia L有着相同的学名。这种植物已被广泛用作抗衰老的草药。在苦瓜中观察到的主要药理作用包括堕胎、降糖、抗菌、抗病毒和抗肿瘤。这些特征与植物化学物质的存在有关，包括皂苷、生物碱、三萜、类固醇和蛋白质。一些化合物已经从所有的植物部位分离出来，如苦瓜素、香瓜素、葫芦素和山茱萸苷。Charantins是一种混合物，在charantia的果实中发现的甾体皂苷具有降血糖活性。许多具有RNA n -糖苷酶、核糖核酸样、抗肿瘤、免疫抑制和抗菌活性的蛋白质和肽也被分离出来，如

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来源期刊

Pharmaceutical Sciences Asia Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

0.90

自引率

0.00%

发文量

期刊介绍： The Pharmaceutical Sciences Asia (PSA) journal is a double-blinded peer-reviewed journal in English published quarterly, by the Faculty of Pharmacy, Mahidol University, Thailand. The PSA journal is formerly known as Mahidol University Journal of Pharmaceutical Sciences and committed to the timely publication of innovative articles and reviews. This journal is available in both printed and electronic formats. The PSA journal aims at establishing a publishing house that is open to all. It aims to disseminate knowledge; provide a learned reference in the field; and establish channels of communication between academic and research expert, policy makers and executives in industry and investment institutions. The journal publishes research articles, review articles, and scientific commentaries on all aspects of the pharmaceutical sciences and multidisciplinary field in health professions and medicine. More specifically, the journal publishes research on all areas of pharmaceutical sciences and related disciplines: Clinical Pharmacy Drug Synthesis and Discovery Targeted-Drug Delivery Pharmaceutics Biopharmaceutical Sciences Phytopharmaceutical Sciences Pharmacology and Toxicology Pharmaceutical Chemistry Nutraceuticals and Functional Foods Natural Products Social, Economic, and Administrative Pharmacy Clinical Drug Evaluation and Drug Policy Making Antimicrobials, Resistance and Infection Control Pharmacokinetics and Pharmacodynamics.