Morphostructural changes in the brain of experimental animals after using mesenchymal stem cells in the temporomandibular joint inflammation model

Q4 Medicine

Proceedings of the National Academy of Sciences of Belarus, Medical series Pub Date : 2023-09-01 DOI:10.29235/1814-6023-2023-20-3-216-225

С. Г. Пашкевич, С. П. Рубникович, Т. Е. Кузнецова, Е. В. Кузьменко, Г. П. Миронова, О. Г. Тихонович, Ж. А. Гладкова, К. Н. Жогаль, Н. С. Сердюченко, А. С. Грищенков, S. Pashkevich, Sergey P . Rubnikovich, Tatyana E . Kuznetsova, Elena V . Kuzmenko, Galina P . Mironova, Olga G . Tikhonovich, Zhanna A. Gladkova, Kseniya N . Zhogal, N. S. Serdyuchenko, Arseny S . Grishchenkov

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Abstract

The article presents the results of structural and functional transformations in cerebellum, trigeminal nuclei, and hippocampus of male Wistar rats against the background of injection of mesenchymal stem cells (MSCs) into Meckel’s space in the temporomandibular joint (TMJ) inflammation model.The aim of the study was to clarify the effect of MSCs injections into Meckel’s space on the morphostructural features of cerebellum, trigeminal nuclei, and hippocampus in the TMJ inflammation model.Injecting the mesenchymal stem cells into Meckel’s space in an inflammatory model of the right lower temporomandibular joint promotes the structure restoration of the ganglionic layer of the cerebellum, the spinal nuclei of the trigeminal nerve, and the hippocampus of rats by the 28th day. This is manifested in increasing the neuronal density, decreasing the neurodegeneration index, and in activating glia elements.

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间充质干细胞用于颞下颌关节炎症模型后实验动物脑形态结构的变化

本文报道了在向颞下颌关节(TMJ)炎症模型中注入间充质干细胞(MSCs)的背景下，雄性Wistar大鼠小脑、三叉神经核和海马的结构和功能改变的结果。本研究旨在阐明MSCs注入Meckel空隙对TMJ炎症模型小脑、三叉神经核和海马形态结构特征的影响。右下颞下颌关节炎性模型Meckel空腔注射间充质干细胞，可促进28天大鼠小脑神经节层、三叉神经脊髓核、海马结构的恢复。表现为神经元密度增加，神经退行性指数降低，神经胶质成分活化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Proceedings of the National Academy of Sciences of Belarus, Medical series Medicine-Medicine (all)

CiteScore

0.40

自引率

0.00%

发文量