Hilda Samimi, Nooshin Shirzad, Sayed Mahmoud Sajjadi-Jazi, Ramin Heshmat, Mahsa M Amoli, Mohammad Reza Mohajeri-Tehrani, Seyed Mohammad Tavangar, Bagher Larijani, Vahid Haghpanah
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引用次数: 0
Abstract
Purpose: Endocrinology and Metabolism Research Institute (EMRI), Tehran University of Medical Sciences, has achieved many advances in the understanding of epidemiology, pathology, and molecular biology of thyroid cancer (TC). This paper will focus on published literature in the field of TC research at EMRI since its inception.
Methods: A comprehensive literature search of "Scopus", "Web of Science (ISI)", "PubMed", and "SID" databases was done to identify TC-based studies in EMRI since 2005, using the predefined keywords.
Results: All the records were reviewed. Eventually, 46 articles that met the inclusion and exclusion criteria were considered. Timeline, characteristics, and summarized findings of the included most studies have been briefly described.
Conclusion: The main focus of the TC research at EMRI is to investigate genetic and epigenetic changes as well as the cellular and molecular aspects seen more frequently in TC patients, and find out how exactly these alterations lead to more aggressive TC behavior and resistance to the conventional treatment approaches in those patients.
目的：德黑兰医科大学内分泌与代谢研究所（EMRI）在甲状腺癌（TC）的流行病学、病理学和分子生物学方面取得了许多进展。本文将重点介绍EMRI自成立以来在TC研究领域发表的文献。方法：对“Scopus”、“Web of Science （ISI）”、“PubMed”和“SID”等数据库进行综合检索，识别2005年以来EMRI中基于cc的研究。结果：对所有记录进行了审核。最终考虑了46篇符合纳入和排除标准的文章。简要描述了所纳入的大多数研究的时间线、特征和总结结果。结论：EMRI研究TC的主要重点是研究TC患者中更常见的遗传和表观遗传变化以及细胞和分子方面的变化，并找出这些改变究竟是如何导致这些患者更具侵略性的TC行为和对常规治疗方法的抵抗。
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