Antitumor Agents 225. Acrofoliones A and B, Two Novel Cytotoxic Acetophenone Dimers from Acronychia Trifoliolata

Abstract

Two novel prenylated acetophenone dimers, acrofoliones A (1) and B (2), were isolated from Acronychia trifoliolata (Rutaceae) to gether with a known cytotoxic principle, acrovestone (3). The new structures were determined from NMR and MS spectroscopic anal y sis. Com pounds 1 and 2 showed only moderate cytotoxicity against HCT-8 and KB cells with ED50 values of 4.3 and 4.8 μg/mL, respectively; how ever, both compounds demonstrated selectivity against MOLT-4 and RPMI-8225 leukemia cell lines.