Formulation, Optimization and Characterization of Solid Dispersion of Glibenclamide

Abstract

Aim: The aim of the present study was to increase the solubility and dissolution of Glibenclamide. Materials and Methods: Various batches of solid dispersion of Glibenclamide using water soluble carriers such as PEG (PEG 4000 and PEG 1500), were prepared as per the design expert (8.0.5) to optimize the drug release profile using response surface methodology (Face centered central composite design). Results: DSC and FTIR were used to characterize the solid dispersions. No chemical interaction was found between Glibenclamide and polymers. F3 and F13 was found to be optimized batch according to the Face centered central composite design (FCCCD). Conclusion: Drug release was directly proportional to the concentration of polymer used for the formulation of solid dispersion. Thus, Glibenclamide with PEG 4000 and PEG 1500 had faster dissolution rate than Glibenclamide itself. Key words : Solid Dispersion, Dissolution, Physical Mixture, Polyethylene Glycol.