Use of a chloride ion selective electrode as a tool for monitoring relatively fast kinetic processes. Application to the hydrolysis of yperite analogues in presence of oximate nucleophiles

Abstract

Experimental conditions have been designed which allowed the use of a chloride ion selective electrode for the mon- itoring of reactions that proceed with a moderately fast departure of Cl - ion, i.e. t1/2 ∪ 40 seconds, in aqueous solution. The pro- cedure has been applied in particular to the hydrolysis of yperite (HD) analogues (CEES, CEMS, CEPS) in aqueous solution in presence of HEPES buffer and oximate nucleophiles. Kinetic parameters were obtained in these conditions and the S N1 mecha- nism for the hydrolysis was confirmed.