Comparison of helical tomotherapy with multi-field intensity-modulated radiotherapy treatment plans using simultaneous integrated boost in high-risk prostate cancer

IF 0.7 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
H. Başaran, S. Karaca, T. Koca, Y. Gündoğdu
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引用次数: 0

Abstract

Abstract Purpose: The aim of this study is to compare the dosimetric results of Helical Tomotherapy (HT) and Multi-field IMRT treatment plans using a Simultaneous Integrated Boost (SIB) technique in the treatment of High-Risk Prostate Cancer (HRPCa) with pelvic nodal radiation. Methods: Seventeen patients planned with HT and 7,8 and 9 fields IMRT were investigated. All plans were designed with the prescribed dose of 54.0 Gy to the PTVln while simultaneously delivering 74.0 Gy to the PTVPS in 30 fractions. Dosimetric data of PTV and OARs were compared. Results: HT gives a better CI and HI of PTVPS compared to multi-field IMRT plans. HT plans significantly improved target coverage (HT:0.95 vs multi-field IMRT: 0.52, 0.49 and 0.49 respectively, p < 0.001). Bladder mean dose(Gy) (HT: 45.6 vs multi-field IMRT: 53.6, 53.3 and 52.7 respectively, p = 0.004) and D66%(Gy) dose (HT: 35.3 vs multi-field IMRT: 46.7, 47.0 and 44.9 respectively, p = 0.006) were lower in HT. But multi-field IMRT plans significantly reduced the rectum volume receiving more than 75 Gy; (HT V75% (%) 2.7 vs multi-field IMRT 0.8, 1.4 and 0.9 respectively, p = 0.008). HT provided better sparing of the right and left femoral head receiving a mean dose. The penile bulb and small bowel doses were the highest in HT compared with multi-field IMRT. Conclusions: HT achieved better dose distribution to target compared to multi-field IMRT. This study suggests HT as a reasonable option for the treatment of HRPCa patients.
螺旋断层治疗与多场调强放疗同时综合增强治疗高危前列腺癌的比较
摘要目的:本研究的目的是比较螺旋断层治疗(HT)和多场IMRT治疗方案采用同步集成Boost (SIB)技术治疗高危前列腺癌(HRPCa)的剂量学结果。方法:对17例计划HT和7、8、9场IMRT的患者进行调查。所有方案设计时,规定剂量为54.0 Gy至PTVln,同时将74.0 Gy分30份递送至PTVPS。比较PTV和OARs的剂量学数据。结果:与多场IMRT方案相比,HT可提供更好的PTVPS CI和HI。HT计划显著提高了目标覆盖率(HT:0.95 vs多场IMRT: 0.52, 0.49和0.49,p < 0.001)。膀胱平均剂量(Gy) (HT: 45.6 vs多场IMRT: 53.6, 53.3和52.7,p = 0.004)和D66%(Gy)剂量(HT: 35.3 vs多场IMRT: 46.7, 47.0和44.9,p = 0.006)较低。但多场IMRT计划显著减少直肠体积接受超过75 Gy;(HT V75% (%) 2.7 vs多场IMRT分别为0.8、1.4和0.9,p = 0.008)。接受平均剂量的HT能更好地保留左右股骨头。与多场IMRT相比,HT的阴茎球和小肠剂量最高。结论:与多场IMRT相比,HT具有更好的剂量分布。本研究提示HT是治疗HRPCa患者的合理选择。
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来源期刊
Polish Journal of Medical Physics and Engineering
Polish Journal of Medical Physics and Engineering RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
1.30
自引率
0.00%
发文量
19
期刊介绍: Polish Journal of Medical Physics and Engineering (PJMPE) (Online ISSN: 1898-0309; Print ISSN: 1425-4689) is an official publication of the Polish Society of Medical Physics. It is a peer-reviewed, open access scientific journal with no publication fees. The issues are published quarterly online. The Journal publishes original contribution in medical physics and biomedical engineering.
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