Anti-Hyperlipidaemic Activity of Aqueous Dried Flower Extract of Hibiscus Sabdariffa Linn. in Albino Mice

Abstract

Aim and objective: The primary objective of the study is to evaluate the antihyperlipidemic of the aqueous extracts of the dried flowers of Hibiscus sabdariffa Linn in rats. Introduction: In the scientific work was presented data of literary sources, which shows that the treatment of diseases that lead to increase in the cholesterol levels is the most common pathological condition of atherosclerosis, which today tends to increase its frequency and remains an urgent problem in modern medicine. It has been proven that the use of compounds of natural origin is effective for the treatment of this pathological condition. Materials and methods: The experimental part presents the results of preclinical biological tests for the study of acute toxicity and the specific pharmacological activity of H. sabdariffa Laboratory pharmacological, physiological, toxicological and methods of mathematical statistics are used in this work. Results and discussions: According to the results of the conducted preliminary phytochemical screening of the developed medicinal product, contains phytochemical constituents like carbohydrates, glycosides, flavonoids, saponins, terpenoids, tannins and fixed oils. The Aqueous dried flower extract of the H.sabdariffa Linn. shows the significant decrease in the total cholesterol level, rise in the HDL cholesterol level and the decrease in the HDL / total cholesterol level and also increase in the locomotory activity at a dose of 50mg/kg. The results suggest that the aqueous extract of the dried flowers of H. Sabdariffa Linn. possess the anti-hyperlipidaemic activity. The observed effects are due to the presence of bioactive substances.