The Inflammatory Markers C-reactive Protein and Mean Platelet Volume in Chronic Kidney Disease

İ. Kılıç, Elif Tuğba Oğuz Taylan, İ. Kurultak, S. Üstündağ
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Abstract

Background: People with chronic kidney disease (CKD) experience chronic systemic inflammation. Although a relationship exists between inflammation and renal injury, the association between inflammatory markers and renal disease has not been well-studied. As inflammation may be a trigger or a result of chronic disease, the kidney needs to be investigated to determine whether it is a clearer target for the devastating effects of persistent inflammation. Here, we report the relation of C-reactive protein and mean platelet volume levels with renal functions in chronic kidney disease patients. Methods: This study was an observational retrospective single-center study conducted on the record of CKD patients to detect the outcomes over a median follow-up time of three years. Demographic, clinical, laboratory, medication, and outcome data were obtained from the electronic data records of the hospital. We investigated the multivariable association of plasma levels of C-reactive protein and mean platelet volume with the progression of CKD in the study participants. Findings: Elevated plasma levels of C-reactive protein (r=0.13, P<0.001) and mean platelet volume (r=0.23, P<0.001) were associated with a greater loss of kidney function over time. The presence of diabetes mellitus was detected to be a risk factor for CKD progression (P=0.04). An inverse relationship was detected between sodium and creatinine (P<0.001). In addition, a weak association was detected between uric acid and creatinine (P<0.001). Conclusion: Elevated plasma levels of C-reactive protein and mean platelet volume were associated with a decline in the estimated glomerular filtration rate in patients with CKD.
慢性肾脏疾病的炎症标志物c反应蛋白和平均血小板体积
背景:慢性肾脏疾病(CKD)患者经历慢性全身性炎症。虽然炎症与肾损伤之间存在关系,但炎症标志物与肾脏疾病之间的关系尚未得到充分研究。由于炎症可能是慢性疾病的触发因素,也可能是慢性疾病的结果,因此需要对肾脏进行研究,以确定它是否是持久炎症破坏性影响的更明确目标。在这里,我们报告了慢性肾病患者c反应蛋白和平均血小板体积水平与肾功能的关系。方法:本研究是一项观察性回顾性单中心研究,对CKD患者进行记录,以检测中位随访时间为三年的结果。人口统计、临床、实验室、用药和结局数据均来自医院的电子数据记录。我们研究了研究参与者血浆c反应蛋白水平和平均血小板体积与CKD进展的多变量关联。结果:随着时间的推移,血浆c反应蛋白水平升高(r=0.13, P<0.001)和平均血小板体积升高(r=0.23, P<0.001)与肾功能的严重丧失相关。糖尿病的存在是CKD进展的危险因素(P=0.04)。钠与肌酐呈负相关(P<0.001)。此外,在尿酸和肌酐之间检测到弱关联(P<0.001)。结论:血浆c反应蛋白水平和平均血小板体积升高与CKD患者肾小球滤过率下降有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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