Prognostic value of neutrophil-lymphocyte ratio in patients with acute respiratory distress syndrome

Abstract

Objective To explore the prognostic value of neutrophil-to-lymphocyte ratio (NLR) in acute respiratory distress syndrome (ARDS). Methods ARDS patients visiting the Second People′s Hospital of Suzhou Xiangcheng and Eastern District of Suzhou Municipal Hospital from January 2016 to October 2018 were enrolled and clinical information were recorded.Correlation analysis, multivariate regression analysis, and survival analysis were used to explore the prognostic value of NLR. Results A total of 80 ARDS patients were included and the median value of NLR was 14.The age, proportion of invasive mechanical ventilation, NLR, and creatinine in non-surviving patients were significantly higher than those in surviving patients, while oxygenation index and plasma albumin in non-surviving patients were significantly lower than those in surviving patients.NLR was significantly associated with overall survival (HR=1.011, 95%CI: 1.004-1.017, P=0.001). In the multivariate Cox regression model, it was further identified that NLR>14 as an independent prognostic factor for overall survival (HR=1.532, 95%CI: 1.095-2.143, P=0.001 3). Hospitalized mortality, 28-day mortality, 90-day mortality, and proportion of invasive mechanical ventilation in ARDS patients with NLR>14 were significantly higher than those with NLR≤14. Conclusions NLR>14 is an independent poor prognostic factor in the early diagnosis of ARDS (24 hours). Key words: Neutrophil-to-lymphocyte ratio; Respiratory distress syndrome, adult; Prognosis