The Potential of Pasak Bumi as a Food Supplement to Improve Spermatogenesis in Mice Model of Malnutrition

Jurnal Berkala Kesehatan Pub Date : 2021-05-31 DOI:10.20527/JBK.V7I1.10526

Ida Yuliana, T. Triawanti, D. Sanyoto, H. Khatimah, A. Asnawati, Rayatul Aminah

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Abstract

Malnutrition causes disruption of spermatogenesis in children. Pasak Bumi has the potential to increase spermatogenesis due to malnutrition. Aimed of research is to proved Pasak Bumi as a food supplement to improve spermatogenesis disorders due to malnutrition in malnourished rats. The research method used analytical observational method by observing the histological preparations of the testes of malnourished rats. Observations using a binocular microscope were analyzed with Optilab Camera and Image Raster software. There are 5 groups of experimental: M: malnutrition without intervention; P1: malnutrition + standard feed + PB 7.5 mg/kgBW; P2: malnutrition + standard feed + PB 15 mg/kgBW; P3: malnutrition + standard feed + PB 22.5 mg/kgBW; P4: malnutrition + standard feed + PB 30 mg/kgBW; Research parameters were number of seminiferous tubules, primary spermatocytes and Leydig cells. Data analysis used the Anova One way test with a confidence level of 95%. The results showed number of seminiferous tubules, primary spermatocytes and Leydig cells in the M group was less than the P1-P4 group. This suggests malnutrition causes disruption of spermatogenesis. Conclusion the administration of Pasak Bumi extract at various doses increased spermatogenesis in malnourished.

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巴沙乌米作为一种食物补充剂促进营养不良小鼠精子发生的潜力

营养不良导致儿童精子发生障碍。由于营养不良，Pasak Bumi有可能增加精子的发生。研究的目的是证明Pasak Bumi作为一种食物补充剂，可以改善营养不良大鼠因营养不良引起的精子发生障碍。研究方法采用分析观察法，通过观察营养不良大鼠睾丸的组织学准备。使用Optilab Camera和Image Raster软件对双目显微镜观察结果进行分析。实验分为5组:M:营养不良不干预;P1:营养不良+标准饲料+铅7.5 mg/kgBW;P2:营养不良+标准饲料+ PB 15 mg/kgBW;P3:营养不良+标准饲料+ PB 22.5 mg/kgBW;P4:营养不良+标准饲料+ PB 30 mg/kgBW;研究参数为精小管数量、原代精母细胞数量和间质细胞数量。数据分析采用单因素方差分析，置信水平为95%。结果显示，M组精小管、原代精母细胞和间质细胞数量少于P1-P4组。这表明营养不良导致精子发生中断。结论不同剂量的巴沙提取物可促进营养不良患者的精子生成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Jurnal Berkala Kesehatan

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