Systemic mastocytosis associated with acute myeloid leukaemia

IF 0.8 Q3 MEDICINE, GENERAL & INTERNAL

Bangladesh Journal of Medical Science Pub Date : 2023-09-07 DOI:10.3329/bjms.v22i4.67129

Mohd Nasiruddin Dhamirah Nazihah, Wan Suriana, Hussain Faezahtul Arbaeyah, Husin Azlan, Saidin Nur Ilyia Syazwani, H. M. Nazri, Z. Zefarina, M. Y. Shafini, Iberahim Salfarina, Mohd Noor Noor Haslina

{"title":"Systemic mastocytosis associated with acute myeloid leukaemia","authors":"Mohd Nasiruddin Dhamirah Nazihah, Wan Suriana, Hussain Faezahtul Arbaeyah, Husin Azlan, Saidin Nur Ilyia Syazwani, H. M. Nazri, Z. Zefarina, M. Y. Shafini, Iberahim Salfarina, Mohd Noor Noor Haslina","doi":"10.3329/bjms.v22i4.67129","DOIUrl":null,"url":null,"abstract":"Bacground: The pathogenesis of systemic mastocytosis with associated haematological neoplasm (SMAHN) is not well understood. Both diagnoses heavily rely on morphological evaluation because SM is rarely suspected in clinical practise.\nObjective: This case highlighted a possible delay in diagnosis due to underlying conditions or diseases.\nCase Report: We present a case of a patient with acute myeloid leukaemia (AML), acute myelomonocytic subtype, and concurrent mastocytosis according to World Health Organization (WHO) classification. Due to an extensive accumulation of AML blast cells that obscured the mast cell infiltrates, mastocytosis was not evident at the first diagnosis.\nDiscussion and conclusion: The diagnosis, in this case, was established only in the third bone marrow biopsy after chemotherapy. A high index of suspicion with morphological and immunohistochemical evaluations for neoplastic mast cell populations should be considered. The optimal treatment approach should be chosen based on these two disease entities.\nBangladesh Journal of Medical Science Vol. 22 No. 04 October’23 Page : 937-941","PeriodicalId":8696,"journal":{"name":"Bangladesh Journal of Medical Science","volume":"171 1","pages":""},"PeriodicalIF":0.8000,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bangladesh Journal of Medical Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3329/bjms.v22i4.67129","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}

引用次数: 0

Abstract

Bacground: The pathogenesis of systemic mastocytosis with associated haematological neoplasm (SMAHN) is not well understood. Both diagnoses heavily rely on morphological evaluation because SM is rarely suspected in clinical practise. Objective: This case highlighted a possible delay in diagnosis due to underlying conditions or diseases. Case Report: We present a case of a patient with acute myeloid leukaemia (AML), acute myelomonocytic subtype, and concurrent mastocytosis according to World Health Organization (WHO) classification. Due to an extensive accumulation of AML blast cells that obscured the mast cell infiltrates, mastocytosis was not evident at the first diagnosis. Discussion and conclusion: The diagnosis, in this case, was established only in the third bone marrow biopsy after chemotherapy. A high index of suspicion with morphological and immunohistochemical evaluations for neoplastic mast cell populations should be considered. The optimal treatment approach should be chosen based on these two disease entities. Bangladesh Journal of Medical Science Vol. 22 No. 04 October’23 Page : 937-941

查看原文本刊更多论文

系统性肥大细胞增多症与急性髓性白血病相关

背景:系统性肥大细胞增多症合并相关血液学肿瘤(SMAHN)的发病机制尚不清楚。这两种诊断都严重依赖于形态学评估，因为SM在临床实践中很少被怀疑。目的:本病例强调了由于潜在的条件或疾病可能延误诊断。病例报告:我们提出了一例患者急性髓性白血病(AML)，急性髓单核细胞亚型，并发肥大细胞增多症根据世界卫生组织(WHO)的分类。由于AML母细胞的大量积聚掩盖了肥大细胞的浸润，因此首次诊断时肥大细胞增多症并不明显。讨论与结论:本病例的诊断仅在化疗后的第三次骨髓活检中确定。对肿瘤肥大细胞群进行形态学和免疫组化评价时应考虑高度怀疑。应根据这两种疾病实体选择最佳治疗方案。孟加拉国医学杂志，第22卷第4期，23年10月，第937-941页

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊