A comparative study of three scoring systems on palpable breast aspirates at a tertiary health-care center: A cross-sectional study

Q3 Biochemistry, Genetics and Molecular Biology
K. Raju, V. Rajanna
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引用次数: 0

Abstract

Background: The cytological grading system in fine-needle aspiration of breast lumps helps the surgeons to decide the method of management and assess the survival rate. However, till date, no single cytological grading system for breast aspirates has been adapted in routine practice. Hence, a comparative study of three different grading systems was done. Materials and Methods: This is a retrospective study conducted from January 2016 to June 2018. The stained aspirated smears of breast lump were assessed for cytomorphologic features and graded as per the Modified Masood's Scoring Index (MMSI), National Cancer Institute (NCI) Cytological Grading System, and Robinson's cytological grading and compared with histological diagnosis (four categories) and modified Scarff–Bloom–Richardson's scoring system (carcinoma cases). Results: The MMSI system had a sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and diagnostic accuracy of 80%, 100%, 100%, 92.86%, and 94.44%, respectively. The NCI system had a sensitivity, specificity, PPV, NPV, and diagnostic accuracy of 60%, 97.44%, 90.0%, 86.36%, and 87.04%, respectively. The Robinson's cytological grading system had a sensitivity, specificity, PPV, NPV, and diagnostic accuracy of 100%, 84.62%, 71.43%, 100%, and 88.89%, respectively. Conclusion: Robinson's scoring system is the system with maximum sensitivity and is most effective in subcategorizing only malignant breast lesions. MMSI is the system with maximum specificity, PPV, and diagnostic accuracy, and can be considered as the standard grading system for both benign and malignant breast lesions on cytology.
三级医疗保健中心可触及乳腺吸物的三种评分系统的比较研究:一项横断面研究
背景:细针抽吸乳腺肿块的细胞学分级系统有助于外科医生决定处理方法和评估生存率。然而,迄今为止,没有一个单一的细胞学分级系统乳腺吸液已适应在常规实践。因此,对三种不同的分级制度进行了比较研究。材料和方法:这是一项回顾性研究,于2016年1月至2018年6月进行。采用改良Masood评分指数(MMSI)、美国国家癌症研究所(NCI)细胞学分级系统和Robinson细胞学分级,对乳腺肿块的染色抽吸涂片进行细胞形态学特征评估,并与组织学诊断(四类)和改良Scarff-Bloom-Richardson评分系统(癌病例)进行比较。结果:MMSI系统的敏感性、特异性、阳性预测值(PPV)、阴性预测值(NPV)和诊断准确率分别为80%、100%、100%、92.86%和94.44%。NCI系统的敏感性、特异性、PPV、NPV和诊断准确率分别为60%、97.44%、90.0%、86.36%和87.04%。罗宾逊细胞学分级系统的敏感性、特异性、PPV、NPV和诊断准确率分别为100%、84.62%、71.43%、100%和88.89%。结论:罗宾逊评分系统是灵敏度最高、仅对乳腺恶性病变进行亚分类最有效的评分系统。MMSI是特异性、PPV和诊断准确性最高的系统,可作为细胞学上乳腺良恶性病变的标准分级系统。
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来源期刊
Journal of Natural Science, Biology, and Medicine
Journal of Natural Science, Biology, and Medicine Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
2.40
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0.00%
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0
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