OVOCIDAL ACTIVITY OF THE COMBINED DRUG AGAINST TOXOCARA CANIS EGGS IN AN IN VITRO LABORATORY EXPERIMENT

THEORY AND PRACTICE OF PARASITIC DISEASE CONTROL Pub Date : 2023-04-17 DOI:10.31016/978-5-6048555-6-0.2023.24.408-413

R. Safiullin

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Abstract

To control helminth infections in carnivores, scientists and practitioners have proposed a number of drugs and agents against both endogenous and exogenous stages. The problem of toxocariasis in carnivores continues to pose challenges for researchers, namely, to improve measures to control the exogenous stage of egg development. Of the modern drugs used against the exogenous stages of Toxocara egg development in carnivores, we should note chlorine-, phenol-, iodine-, caustic alkalis-based drugs and others which are mostly monovalent and do not meet the requirements of veterinary practice in terms of their efficacy. Based on the above, we set ourselves the task of testing the ovocidal activity of the combined agent Сystodesis consisting of glutaraldehyde, alkyldimethylbenzylammonium chloride, isopropyl alcohol, and polyethylene glycol-400 against Toxocara canis eggs in an in vitro laboratory experiment. The combined agent of disinvasion Сystodesis at 3% concentration showed 94.06% intense-effectiveness in an in vitro laboratory experiment against Toxocara canis eggs. The intense-effectiveness of the test agent at 4 and 5% concentrations against Toxocara eggs in dogs was 100%. The comparator 4% phenol provided 86.5% intense-effectiveness.

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联合用药对犬弓形虫卵的卵泡活性体外实验研究

为了控制食肉动物的蠕虫感染，科学家和从业者已经提出了许多针对内源性和外源性阶段的药物和制剂。食肉动物的弓形虫病问题继续给研究人员带来挑战，即改进控制卵发育外源阶段的措施。在用于对抗食肉动物弓形虫卵外源性发育阶段的现代药物中，我们应该注意氯、酚、碘、苛性碱等药物，它们大多是单价的，在功效方面不符合兽医实践的要求。在此基础上，我们为自己设定了在体外实验室实验中测试由戊二醛、烷基二甲基苄基氯化铵、异丙醇和聚乙二醇-400组成的联合剂Сystodesis对犬弓形虫卵的产卵活性。在体外实验中，3%浓度的消侵Сystodesis联合剂对犬弓形虫卵的强效率为94.06%。浓度为4%和5%的试验剂对犬弓形虫卵的强效为100%。比较物4%苯酚的强效率为86.5%。

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THEORY AND PRACTICE OF PARASITIC DISEASE CONTROL

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