Advances in the study of the pathogenesis of cancer-related cognitive impairment

Jiwei Jiang, Z. Du, Yanli Wang, H. Shi, Wenyi Li, Yuan Zhang, Mengfan Sun, Zhimin Bian, Jun Xu
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Abstract

Advances in diagnostic and therapeutic strategies have significantly contributed to an increase in the survival rate of cancer patients. Recently, several studies suggested that cancer patients may exhibit symptoms of cognitive impairment before, during and even many years after the completion of therapies, negatively impacting the quality of life and functional independence of cancer survivors. Clinically, the coexistence of cancer and cognitive impairment reminds scientists of paraneoplastic syndrome, especially limbic encephalitis. However, some cancer patients show symptoms of cognition deterioration after treatment, without any typical psychiatric symptoms, epileptic seizures or positive antineuronal antibodies, suggesting that the relationship between cancer and cognitive deficits is more common than previously anticipated. Most importantly, many aspects of the association between cancer and cognitive impairment remain uncertain. The definitive connection between systemic cancer and central nervous system is yet to be established. Therefore, this review summarizes the current evidence on the potential pathophysiology in these patients with cancer-related cognitive impairment, and reviews the knowledge gaps and the potential counteracting strategies.
癌症相关认知障碍发病机制的研究进展
诊断和治疗策略的进步大大提高了癌症患者的存活率。最近,一些研究表明,癌症患者在治疗完成之前、期间甚至多年后可能会出现认知障碍症状,对癌症幸存者的生活质量和功能独立性产生负面影响。在临床上,癌症与认知功能障碍的共存让科学家们想起了副肿瘤综合征,尤其是边缘脑炎。然而,一些癌症患者在治疗后表现出认知恶化的症状,没有任何典型的精神症状、癫痫发作或抗神经元抗体阳性,这表明癌症与认知缺陷之间的关系比之前预期的更为普遍。最重要的是,癌症和认知障碍之间的关系在许多方面仍不确定。全身性癌症和中枢神经系统之间的确切联系尚未确定。因此,本文综述了目前关于这些癌症相关认知障碍患者潜在病理生理的证据,并对知识差距和潜在的对抗策略进行了综述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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