Antihypertensive Activity of Aqueous Extract of Adhatoda Vasica in Hypertensive Rats.

Abstract

The present study involved the evaluation of effectiveness of aqueous extract of Adhatoda Vasica on blood pressure, Systolic blood pressure, diastolic blood pressure and mean arterial blood pressure in the hypertensive rats. The result of present study was shown that the pretreatment with aqueous extract of adhatoda vasica (100, 200 & 400mg/Kg p.o) for six week and on the day of experiment after administration of aqueous extract of adhatoda Vasica (10, 20 & 40mg/kg i.v.) produced significant reduction in BP, SBP, DBP and MABP at different time interval in dose dependant manner. The positive control, Captopril at the dose of 1mg/kg was shown significant decrease in the elevated blood pressure in Goldblatt model. It reveals that antihypertensive effect observed for aqueous extract of adhatoda vasica in present study due to decrease rennin release and angiotensin II levels: AT1 and AT2 receptors antagonism: inhibition of aldosterone secreation: increased prostaglandin synthesis or inhibition of ACE that is involved in angiotensin II from angiotensin I. -------------------------------------------------------------------------------------------------------------------------------------Date of Submission: xx-xx-xxxx Date of acceptance: xx-xx-xxxx -------------------------------------------------------------------------------------------------------------------------------------