Mesenchymal stem cells: applications in immuno-cell therapy

Abstract

Mesenchymal stromal cells(MSCs) have been exploited for their immunomodulatory properties in treating various immune-related disorders. MSCs can modulate the immune system through interactions with a variety of immune cells. Regardless of the researchers focused on understanding how MSCs connect to individual immune system cell subsets, the mechanisms for inducing restorative effect still stay mainly undiscovered. Through this mini-review we address what is known about the associations and effects of educated MSCs with cells of the innate immune system (macrophages and neutrophils) and our knowledge of these interactions will be essential in increasing and expanding new medical protocols for MSC based cell therapy in the foreseeable future Mesenchymal stem cells: applications in immuno-cell therapy Nasim Rahmani Kukia1, Payam Zandi2, Ardeshir Abbasi3* 1Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran 2Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University Tehran, Iran 3Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran