Usefulness of Elevated Troponin to Predict Severity in Patients with COVID-19

University Heart Journal Pub Date : 2022-01-31 DOI:10.3329/uhj.v18i1.57877

Kazi Alam Nowaz, A. Haque, Syeda Aleya Sultana, M. A. Malek, W. Rahman, M. Kamal, Md Sanaul Haque, J. Farjana, Md Noornabi Khondaker

{"title":"Usefulness of Elevated Troponin to Predict Severity in Patients with COVID-19","authors":"Kazi Alam Nowaz, A. Haque, Syeda Aleya Sultana, M. A. Malek, W. Rahman, M. Kamal, Md Sanaul Haque, J. Farjana, Md Noornabi Khondaker","doi":"10.3329/uhj.v18i1.57877","DOIUrl":null,"url":null,"abstract":"Background: Coronavirus disease 2019 (COVID-19) has produced a significant health burden worldwide. Recent studies had shown that cardiac injury in COVID-19 is not uncommon and may leads to death. The aim of this study was to assess cardiac troponin in patients with COVID-19 and to evaluate the incidence of myocardial injury. \nMethods: A cross-sectional study was designed among 100 hospitalized patients with moderate to severe COVID-19 in Combined Military Hospital (CMH), Dhaka from January to April, 2021, after considering inclusion and exclusion criteria, study population was divided into two groups on the basis of normal and elevated troponin level. \nResults: Participants had mean age of 67.33 ± 7.63 years with 76% men. 42% population had elevation in troponin levels. Risk factors like age, Diabetes (DM), C-reactive protein (CRP), Lactate dehydrogenase (LDH), D- Dimer, Ferrtin level were more in elevated troponin group and statistically significant. Troponin levels significantly increased with increasing severity of COVID-19 staging (Kendall’s tau-b =0.479, p= 0.004) with reflected moderate positive correlation. Multivariate analysis was performed for association of COVID- 19 severity with elevated troponin separately after adjusting for other known confounding factors. Independent association between COVID-19 severity and troponin remained significant after that along with other acute phase reactants and inflammatory markers. \nConclusion: COVID-19 can significantly leads to myocardial injury. This data suggested elevated troponin level is one of the determinants of clinical outcome in patients with COVID-19. \nUniversity Heart Journal 2022; 18(1): 29-35","PeriodicalId":23424,"journal":{"name":"University Heart Journal","volume":"4 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"University Heart Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3329/uhj.v18i1.57877","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Coronavirus disease 2019 (COVID-19) has produced a significant health burden worldwide. Recent studies had shown that cardiac injury in COVID-19 is not uncommon and may leads to death. The aim of this study was to assess cardiac troponin in patients with COVID-19 and to evaluate the incidence of myocardial injury. Methods: A cross-sectional study was designed among 100 hospitalized patients with moderate to severe COVID-19 in Combined Military Hospital (CMH), Dhaka from January to April, 2021, after considering inclusion and exclusion criteria, study population was divided into two groups on the basis of normal and elevated troponin level. Results: Participants had mean age of 67.33 ± 7.63 years with 76% men. 42% population had elevation in troponin levels. Risk factors like age, Diabetes (DM), C-reactive protein (CRP), Lactate dehydrogenase (LDH), D- Dimer, Ferrtin level were more in elevated troponin group and statistically significant. Troponin levels significantly increased with increasing severity of COVID-19 staging (Kendall’s tau-b =0.479, p= 0.004) with reflected moderate positive correlation. Multivariate analysis was performed for association of COVID- 19 severity with elevated troponin separately after adjusting for other known confounding factors. Independent association between COVID-19 severity and troponin remained significant after that along with other acute phase reactants and inflammatory markers. Conclusion: COVID-19 can significantly leads to myocardial injury. This data suggested elevated troponin level is one of the determinants of clinical outcome in patients with COVID-19. University Heart Journal 2022; 18(1): 29-35

查看原文本刊更多论文

肌钙蛋白升高预测COVID-19患者严重程度的有效性

背景:2019冠状病毒病(COVID-19)在全球范围内造成了重大的健康负担。最近的研究表明，COVID-19患者的心脏损伤并不罕见，并可能导致死亡。本研究的目的是评估COVID-19患者的心肌肌钙蛋白水平，并评估心肌损伤的发生率。方法:对2021年1 - 4月在达卡联合军队医院(CMH)住院的100例中重度新冠肺炎患者进行横断面研究，综合考虑纳入和排除标准，根据肌钙蛋白水平正常和升高将研究人群分为两组。结果:参与者平均年龄67.33±7.63岁，其中76%为男性。42%的人群肌钙蛋白水平升高。年龄、糖尿病(DM)、c反应蛋白(CRP)、乳酸脱氢酶(LDH)、D-二聚体(D - Dimer)、铁蛋白(Ferrtin)等危险因素在肌钙蛋白升高组明显增高，且差异有统计学意义。肌钙蛋白水平随COVID-19分期严重程度的增加而显著升高(Kendall 's tau-b =0.479, p= 0.004)，呈中度正相关。在调整其他已知混杂因素后，分别对COVID- 19严重程度与肌钙蛋白升高的相关性进行多因素分析。之后，肌钙蛋白以及其他急性期反应物和炎症标志物与COVID-19严重程度之间的独立关联仍然显著。结论:COVID-19可显著导致心肌损伤。这些数据表明，肌钙蛋白水平升高是COVID-19患者临床结果的决定因素之一。大学心脏杂志2022;18 (1): 29-35

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

University Heart Journal

自引率

0.00%

发文量