Efficacy of Single Versus Split Dose Polyethylene Glycol for Colonic Preparation in Children: A Randomized Control Study.

Abstract

OBJECTIVES Polyethylene glycol (PEG) is the most effective colon cleansing agent but volume related adverse effects are common. Though split-dose PEG is used in adults, no pediatric study so-far has compared split-dose with single-dose PEG. We aimed at comparing the efficacy and tolerability of split-dose versus single-dose PEG for bowel preparation in children. METHODS Consecutive children (1-18 years) were randomized into either single-dose or split-dose PEG. Single-dose group received 4000 mL/1.73mPEG solution day before colonoscopy while split-dose group received half dose day before and the remaining half on the day of colonoscopy. Effectiveness of bowel preparation was assessed on Aronchik scale, by the endoscopist who was blinded to the type of preparation. Inter-observer variability was analyzed by comparing with independent scoring by the blinded trained endoscopy-nurse. The trial was registered with Clinical Trials Registry of India. (Trail number2017/08/009303) RESULTS:: Of the 220 randomized children, 179 completed the study (split-dose: 93, single-dose: 86) The mean age of the study population was 11.51 (4.82) years (72.6%males). The efficacy of bowel preparation was better with split-dose (satisfactory preparation:76.34% vs. 43.02%, p < 0.001) with almost perfect inter-observer agreement (k = 0.803). Nausea, vomiting and sleep disturbance were significantly less in split-dose than single-dose group (p < 0.05). Split-dose patients were able to drink PEG solution faster (p = 0.002). Total sleep duration and uninterrupted sleep duration was also better in split-dose group as compared to single-dose (p = 0.001). CONCLUSIONS Split-dose PEG is more effective than single-dose regimen for bowel preparation with better tolerability and improved sleep quality in pediatric population.