Inferior Liver Transplant Outcomes during early COVID-19 pandemic in United States.

IF 1.8 4区地球科学 Q3 GEOSCIENCES, MULTIDISCIPLINARY

Journal of Petroleum Geology Pub Date : 2022-07-01 Epub Date: 2022-05-16 DOI:10.1016/j.liver.2022.100099

Kenji Okumura, Seigo Nishida, Hiroshi Sogawa, Gregory Veillette, Roxana Bodin, David C Wolf, Abhay Dhand

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引用次数: 4

Abstract

Background: : Since its declaration as a global pandemic on March11^th 2020, COVID-19 has had a significant effect on solid-organ transplantation. The aim of this study was to analyze the impact of COVID-19 on Liver transplantation (LT) in United States.

Methods: : We retrospectively analyzed the United Network for Organ Sharing database regarding characteristics of donors, adult-LT recipients, and transplant outcomes during early-COVID period (March 11- September 11, 2020) and compared them to pre-COVID period (March 11 - September 11, 2019).

Results: : Overall, 4% fewer LTs were performed during early-COVID period (4107 vs 4277). Compared to pre-COVID period, transplants performed in early-COVID period were associated with: increase in alcoholic liver disease as most common primary diagnosis (1315 vs 1187, P< 0.01), higher MELD score in the recipients (25 vs 23, P<0.01), lower time on wait-list (52 vs 84 days, P<0.01), higher need for hemodialysis at transplant (9.4 vs 11.1%, P=0.012), longer distance from recipient hospital (131 vs 64 miles, P<0.01) and higher donor risk index (1.65 vs 1.55, P<0.01). Early-COVID period saw increase in rejection episodes before discharge (4.6 vs 3.4%, P=0.023) and lower 90-day graft/patient survival (90.2 vs 95.1 %, P<0.01; 92.2 vs 96.5 %, P<0.01). In multivariable cox-regression analysis, early-COVID period was the independent risk factor for graft failure at 90-days post-transplant (Hazard Ratio 1.77, P<0.01).

Conclusions: : During early-COVID period in United States, overall LT decreased, alcoholic liver disease was primary diagnosis for LT, rate of rejection episodes before discharge was higher and 90-days post-transplant graft survival was lower.

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美国早期COVID-19大流行期间的劣质肝移植结果

背景:自2020年3月11日宣布为全球大流行以来，COVID-19对实体器官移植产生了重大影响。本研究的目的是分析COVID-19对美国肝移植(LT)的影响。方法:我们回顾性分析了联合器官共享网络数据库中covid早期(2020年3月11日至9月11日)供体、成人肝移植受体和移植结果的特征，并将其与covid前(2019年3月11日至9月11日)进行了比较。结果:总体而言，在covid - 19早期进行的LTs减少了4%(4107例对4277例)。与covid - 19前相比，在covid - 19早期进行移植与以下因素相关:酒精性肝病(最常见的原发性诊断)增加(1315 vs 1187, P< 0.01)，受者MELD评分较高(25 vs 23, PPP=0.012)，离受者医院的距离较远(131 vs 64英里，PPP=0.023)，移植/患者90天生存率较低(90.2% vs 95.1%， PPP)。在美国的早期covid期间，总体LT下降，酒精性肝病是LT的主要诊断，出院前排斥事件发生率较高，移植后90天存活率较低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Petroleum Geology 地学-地球科学综合

CiteScore

3.40

自引率

11.10%

发文量

审稿时长

6 months

期刊介绍： Journal of Petroleum Geology is a quarterly journal devoted to the geology of oil and natural gas. Editorial preference is given to original papers on oilfield regions of the world outside North America and on topics of general application in petroleum exploration and development operations, including geochemical and geophysical studies, basin modelling and reservoir evaluation.