TRPC 6 as a Molecular Target in Diabetic Nephropathy

Abstract

Transient Receptor Potential Canonical (TRPC6) assumes vital part in pathophysiology of DN and is up-regulated by angiotensin II, high glucose level, Transforming growth factor beta (TGFβ), and intercede podocyte damage in Diabetes Mellitus focusing on TRPC6 may reduce podocyte damage and proteinuria. From different investigation and proof gave by analyst and author work on pathophysiological part of TRPC 6 and the medications which modify or restrain TRPC6 or its downstream molecular target propose that TRPC6 is novel molecular target. Recently distinguished ROS/TRPC6 pathway will cover the best approach to new, reassuring restorative systems to target kidney ailments, especially Diabetic Nephropathy. Key-wordsDiabetic nephropathy, TRPC6, Podocyte Injury, Proteinuria INTRODUCTION Transient receptor potential (TRP) channels are a large family of proteins with six main subfamilies named as TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPP (polycystin), TRPML (mucolipin), and TRPA (ankyrin) sets . Classification on the basis of Amino acids Mammalian TRP channel proteins form six transmembrane cation-permeable channels that may be clustered into six subfamilies on the basis of amino acid arrangement (TRPC, TRPV, TRPM, TRPA, TRPP, and TRPML) . Many TRPs are expressed in kidney along diverse parts of the nephron and growing confirmation propose that these channels are tangled in hereditary, as well as acquired kidney disorders . The total number of different TRPs with diverse functions supports the announcement that these channels are tangled in a wide range of processes ranging from distinguishing of thermal and chemical signals to reloading intracellular stores after responding to an extracellular stimulus. Mutations in TRPs are associated to pathophysiology and specific diseases [1] Pathophysiological role of Transient Receptor Potential (TRP) Channels TRP melastatin (TRPM2) non-selective cation channels are expressed in the cytoplasm & intracellular organelles, Access this article online Quick Response Code Website: