A pilot study of changes in urinary podocalyxin levels during normal pregnancy and labor

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL
Ylbe Palacios de Franco, N. Segovia, Ylbe Franco Marx, Rudiona Hoxhaj, Carlos Franco Palacios
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Abstract

Abstract Introduction: Increased urinary podocalyxin, a surrogate marker of podocyte detachment, has been shown in preeclampsia and eclampsia, but there is a paucity of data of the effect of normal pregnancy on its urinary excretion. We aimed to describe these changes in this pilot study. Methods: Urine podocalyxin levels were measured in 115 pregnant women. Of these, 12 women were in the second trimester of gestation, 57 in the third trimester and 46 women were in labor. Results: The median [IQR] urinary podocalyxin levels were 0.81 [0.27, 3.68], 0.92 [0.44, 5.49] and 64.7 [30.5, 106.3] ng/mg creatinine in the second trimester, third trimester, and during labor, respectively (p<0.0001). Patients with hematuria during labor had higher levels of urinary podocalyxin (128.6 [79.8, 169.6] ng/mg creatinine. There was a moderate correlation between gestational age and urinary podocalyxin levels (r=0.63, p<0.0001). Conclusion: Urinary podocalyxin levels were low in normal pregnancies and increased significantly during labor and with hematuria.
正常妊娠和分娩期间尿足alyxin水平变化的初步研究
摘要:尿足alyxin(足细胞脱离的替代标志物)的增加已在子痫前期和子痫中被发现,但缺乏正常妊娠对其尿排泄的影响的数据。我们的目的是在这个初步研究中描述这些变化。方法:测定115例孕妇尿足霉素水平。其中,12名妇女处于妊娠中期,57名处于妊娠晚期,46名妇女处于分娩阶段。结果:妊娠中期、妊娠晚期和分娩时尿足alyxin的中位数[IQR]分别为0.81[0.27,3.68]、0.92[0.44,5.49]和64.7 [30.5,106.3]ng/mg肌酐(p<0.0001)。分娩时有血尿的患者尿足alyxin水平较高(128.6 [79.8,169.6]ng/mg肌酐)。胎龄与尿足alyxin水平有中度相关性(r=0.63, p<0.0001)。结论:尿足alyxin水平在正常妊娠时较低,在分娩和血尿时明显升高。
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来源期刊
Romanian Journal of Internal Medicine
Romanian Journal of Internal Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
5.30%
发文量
35
审稿时长
15 weeks
期刊介绍: Romanian Journal of Physics is a journal publishing physics contributions on the following themes: •Theoretical Physics & Applied Mathematics •Nuclear Physics •Solid State Physics & Materials Science •Statistical Physics & Quantum Mechanics •Optics •Spectroscopy •Plasma & Lasers •Nuclear & Elementary Particles Physics •Atomic and Molecular Physics •Astrophysics •Atmosphere and Earth Science •Environment Protection
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