The Protective Effect of Melatonin on Plasma Lipid Profile in Rats with Cerulein-induced Acute Pancreatitis

Turkish Journal of Sport and Exercise Pub Date : 2019-09-15 DOI:10.15314/tsed.541829

E. Keskin, D. Uluışık

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引用次数: 3

Abstract

ABSTRACT The objective of this study was to assessment the effect of melatonin on lipid profile in rats with experimentally induced acute pancreatitis. In this study, 32 adult, male, healthy Wistar Abino rats were used. Group I animals was no applied. Group II animals was intraperitoneally administered 50 mg/kg melatonin per rat twice for two hours intervals. Animals of group III received two intraperitoneal injections of cerulein (50 µg/kg and 25 µg/kg bw, respectively) at two hours intervals. Animals of group IV received two intraperitoneal injections of cerulein (50 µg/kg and 25 µg/kg bw, respectively) at two hours intervals and the rats received an intraperitoneal injection of 50 mg/kg melatonin 30 min before each cerulein injection. After 12 hours from the last cerulein injection, total cholesterol, triglyceride, LDL, HDL levels was determined. In this study, experimentally induced acute pancreatitis resulted in significantly increase in levels of total cholesterol, triglyceride and LDL (p<0.05) , while HDL level significantly decreased compared with control group level (p<0.05) . Pretreatment of melatonin to the rats with acute pancreatitis importantly reduced triglyceride and LDL levels compared to pancreatitis group (p<0.05) . In conclusion, melatonin pretreatment may alleviate the abnormalities in plasma lipid profile caused by acute pancreatitis.

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褪黑素对蓝蛋白诱导的急性胰腺炎大鼠血脂的保护作用

本研究的目的是评估褪黑素对实验性急性胰腺炎大鼠血脂的影响。本研究选用32只健康成年雄性Wistar Abino大鼠。ⅰ组动物不应用。II组动物每只大鼠腹腔注射褪黑素50 mg/kg，间隔2小时两次。III组动物每隔2小时腹腔注射2次蓝蛋白(分别为50µg/kg和25µg/kg bw)。IV组动物每隔2小时腹腔注射两次蓝蛋白(分别为50µg/kg和25µg/kg bw)，大鼠在每次注射蓝蛋白前30 min腹腔注射褪黑素50 mg/kg。最后一次注射蓝蛋白12小时后，测定总胆固醇、甘油三酯、LDL、HDL水平。在本研究中，实验性急性胰腺炎导致总胆固醇、甘油三酯和LDL水平显著升高(p<0.05)， HDL水平显著低于对照组(p<0.05)。与胰腺炎组相比，褪黑素预处理显著降低了急性胰腺炎大鼠的甘油三酯和LDL水平(p<0.05)。综上所述，褪黑素预处理可减轻急性胰腺炎引起的血脂异常。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Turkish Journal of Sport and Exercise

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