Polarity in skeletal muscle cells is induced by innervation

Steven J. Burden , Sangmee Ahn Jo , Jichen Tang , Xuejun Zhu , James E. Yeadon , Alexander M. Simon
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引用次数: 5

Abstract

Skeletal muscle fibers are specialized at the site of the neuromuscular synapse, and this polarity is acquired during development and maintained in the adult as a consequence of inductive interactions between nerve and muscle. This review summarizes recent experiments which demonstrate that two different signalling pathways, a transcriptional pathway and a post-translational pathway, have an important role in the formation and maintenance of the neuromuscular synapse and mediate the induction of polarity in skeletal muscle fibers.

骨骼肌细胞极性是由神经支配诱导的
骨骼肌纤维在神经肌肉突触的位置是专门的,这种极性是在发育过程中获得的,并在成人中作为神经和肌肉之间的诱导相互作用的结果而保持。本文综述了近年来的实验结果,表明两种不同的信号通路,转录通路和翻译后通路,在神经肌肉突触的形成和维持中起重要作用,并介导骨骼肌纤维极性的诱导。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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