Experimental evaluation of preventive action of baladimandura in gastric ulcer based on histopathological reports

Abstract

Background: Peptic ulcer diseases constitute a major disease that affects the Gastro Intestinal tract. Gastric ulcers are one among the types of Peptic ulcers in which the ulcers are manifested in the lining of gastric mucosa. Annadrava shoola can be correlated with gastric ulcer due to its similarity in symptomatology. Baladimandura is a drug of choice in the management of Amlapitta and Parinamashoola mentioned in Rasakamadhenu. Aims & Objectives: To evaluate the gastric ulcer preventive action of Baladimandura in pyloric ligated albino rats through the histopathology examination of stomach tissue. Methodology: 24 wistar strain albino rats were grouped into 4; all the rats were free access to food and water ad libitum along with standard and test drug to the respective groups for 8 days. On 9th day all the rats were kept for fasting and 10th day pyloric ligation performed followed by sacrificing the rats for taking the stomach tissue for histopathology examination. Results: By comparing the histopathology report of all the rats the test group showed no ulcer formation. However slight inflammation was observed in the test drug group. Discussion & Conclusion: Gastric ulcers are manifested when the gastric mucosal barrier fails to prevent the entry of excess HCL into the cells. Baladimandura acts as Amlapitta hara, Parinama shoola hara and as a powerful ulcer preventive drug due to its gastro protective action.