Mammary analogue secretory carcinoma (MASC) of parotid gland- A case report

IF 0.6 Q3 Medicine

Indian Journal of Otolaryngology and Head and Neck Surgery Pub Date : 2023-08-15 DOI:10.18231/j.ijashnb.2023.014

Pratiksha Pawar, Shubhanshi Kangloo, Ameya Bihani, Kunal G, Chetna B

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引用次数: 0

Abstract

Mammary analogue secretory carcinoma is a rare salivary gland carcinoma which shares morphologic and immunohistochemical features with the secretory carcinoma of breast and was first proposed by Skalova in 2010 with translocation of (q13; q25), t (12; 15), subsequently giving ETV6-NTRK3 gene rearrangement. Usually, it is a benign tumor that affects the parotid gland, with slight predilection for males. The present article report a case of secretory carcinoma of right parotid gland with special emphasis on histological feature and immunohistochemistry for diagnostic purpose and its management. Differential diagnosis includes AciCC, ADC-NOS and MEC. In a review by Chiosa et al (2012) in 337 cases of salivary gland malignancy included AciCC, ADC-NOS, MEC, LGCC, non-ITAC, signet ring adenocarcinoma, PLGA and most common malignancy reclassified as MASC were AciCC (11/89), ADC-NOS (14/37), MEC (1/165). Management for MASC includes surgical excision of the lesion (either superficial or total parotidectomy) for local, less aggressive disease like for low-grade malignant salivary gland neoplasms. For more invasive, metastatic disease and positive margins- neck dissection, radiotherapy and chemotherapy are reserved. There is no standard multidisciplinary treatment protocol established due to scarcity of this disease.

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腮腺乳腺类似分泌性癌(MASC) 1例

乳腺类似分泌性癌是一种罕见的涎腺癌，与乳腺分泌性癌具有相同的形态学和免疫组织化学特征，于2010年由Skalova首次提出，易位为(q13;Q25)， t (12;15)，随后给予ETV6-NTRK3基因重排。通常，它是一种影响腮腺的良性肿瘤，男性略占优势。本文报告1例右腮腺分泌性癌，并着重讨论其组织学特征及免疫组化诊断及治疗。鉴别诊断包括AciCC、ADC-NOS和MEC。Chiosa等(2012)回顾了337例唾液腺恶性肿瘤，包括AciCC、ADC-NOS、MEC、LGCC、非itac、印环腺癌、PLGA，最常见的被重新分类为MASC的恶性肿瘤为AciCC(11/89)、ADC-NOS(14/37)、MEC(1/165)。对于低度恶性唾液腺肿瘤等侵袭性较弱的局部疾病，MASC的治疗包括手术切除病变(浅表或全腮腺切除术)。对于侵袭性、转移性疾病和阳性边缘颈夹层，保留放疗和化疗。由于这种疾病的稀缺性，没有建立标准的多学科治疗方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Indian Journal of Otolaryngology and Head and Neck Surgery Medicine-Otorhinolaryngology

CiteScore

0.90

自引率

0.00%

发文量

226

审稿时长

3 months

期刊介绍： Indian Journal of Otolaryngology and Head & Neck Surgery was founded as Indian Journal of Otolaryngology in 1949 as a scientific Journal published by the Association of Otolaryngologists of India and was later rechristened as IJOHNS to incorporate the changes and progress. IJOHNS, undoubtedly one of the oldest Journals in India, is the official publication of the Association of Otolaryngologists of India and is about to publish it is 67th Volume in 2015. The Journal published quarterly accepts articles in general Oto-Rhino-Laryngology and various subspecialities such as Otology, Rhinology, Laryngology and Phonosurgery, Neurotology, Head and Neck Surgery etc. The Journal acts as a window to showcase and project the clinical and research work done by Otolaryngologists community in India and around the world. It is a continued source of useful clinical information with peer review by eminent Otolaryngologists of repute in their respective fields. The Journal accepts articles pertaining to clinical reports, Clinical studies, Research articles in basic and applied Otolaryngology, short Communications, Clinical records reporting unusual presentations or lesions and new surgical techniques. The journal acts as a catalyst and mirrors the Indian Otolaryngologist’s active interests and pursuits. The Journal also invites articles from senior and experienced authors on interesting topics in Otolaryngology and allied sciences from all over the world. The print version is distributed free to about 4000 members of Association of Otolaryngologists of India and the e-Journal shortly going to make its appearance on the Springer Board can be accessed by all the members. Association of Otolaryngologists of India and M/s Springer India group have come together to co-publish IJOHNS from January 2007 and this bondage is going to provide an impetus to the Journal in terms of international presence and global exposure.