Evaluation of Gastric and Duodenal Antiulcer Activityof Ranitidine Formulation in Experimental Animals

S. Ramach, M. Dhanaraju
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引用次数: 10

Abstract

The present study involves the evaluation of controlled release formulation of Ranitidine for its gastric and duodenal antiulcer activity in rats as animal models. Gastric and duodenal ulcers were produced in rats by pyloric ligation method as described by ShayÂ’et al.[1] and aspirin induced ulcer in rats. The animals were divided separately for both experiments. In each method animals were divided into four groups of six animals each. Group 1 served as normal control in which the animals received only distilled water. Group II served as disease control in which the animals were maintained under same environmental conditions but surgical manipulations done like other groups. Group III received standard drug Ranitidine 50mg/kg orally. Group IV were received Ranitidine formulation respectively with a dose equivalent to Ranitidine 50mg/kg orally by means of suspension. The antiulcer activity of pyloric ligated and aspirin induced animals were correlated for the reduction in ulcer levels. Various parameters likemean volume of gastric secretion,mean pH,mean total acid and ulcer index were calculated and was concluded that the group received Ranitidine formulation exhibited significant antiulcer activity by bothmethods when compared to standard drug Ranitidine. The biopsy report of rat stomach of all the groups were analyzed and was found that rats which received Ranitidine formulation and standard Ranitidine showed good healing of ulcers when compared to disease control group of animals. The mean volume of gastric secretions,mean pH mean total acid and ulcer index for Ranitidine formulation treated group was calculated as 2.67ml, 5.59, 110mEq/l, and 1.74 respectively. From the results it can be concluded that Ranitidine formulation exhibited significant antiulcer effect and the histopathology report also supports and confirm its effect.
雷尼替丁制剂在实验动物胃和十二指肠抗溃疡活性的评价
本研究对雷尼替丁控释制剂的胃和十二指肠抗溃疡活性进行了动物模型评价。ShayÂÂ等[1]采用幽门结扎法和阿司匹林诱导大鼠胃溃疡和十二指肠溃疡。动物被分开进行两项实验。在每种方法中,动物被分成四组,每组6只。第一组作为正常对照,只给动物注射蒸馏水。第二组作为疾病控制,动物保持在相同的环境条件下,但与其他组一样进行手术操作。第三组给予标准药物雷尼替丁50mg/kg口服。IV组分别给予雷尼替丁制剂,剂量相当于雷尼替丁50mg/kg悬浮液口服。幽门结扎动物和阿司匹林诱导动物的抗溃疡活性与溃疡水平的降低相关。计算胃液平均分泌量、平均pH值、平均总酸和溃疡指数等各项参数,得出结论:与标准药物雷尼替丁相比,两种方法均显示雷尼替丁组具有显著的抗溃疡活性。对各组大鼠胃组织活检报告进行分析,发现与疾病对照组相比,给予雷尼替丁制剂和标准雷尼替丁的大鼠溃疡愈合良好。计算雷尼替丁制剂治疗组胃分泌物平均体积、平均pH、平均总酸和溃疡指数分别为2.67ml、5.59、110mEq/l和1.74。结果表明,雷尼替丁制剂具有明显的抗溃疡作用,组织病理学报告也支持和证实了其作用。
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