SYNTHESIS AND CHARACTERIZATION OF PALLADIUM (II)–2- (AZIDOMETHYL)CYCLOPROPANE-1,1-DICARBOXYLIC ACID COMPLEX

M. Kostić, V. Divac, Sven Mangelinckx
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Abstract

The discovery that palladium complexes possess a wide range of biological activities (from antitumor, -viral, -malarial, -fungal to antimicrobial activities) encourages further research in this scientific field. Herein we describe the synthesis and characterization of a novel palladium (II) complex, using [Pd(dien)Cl]Cl and 2-(azidomethyl)cyclopropane-1,1-dicarboxylic acid (azmcpda) as a ligand. [Pd(dien)Cl]Cl was selected as a starting material taking into consideration its importance as a model for the investigation of the substitution reactions in coordination chemistry and a deeper understanding of the biological activities of some structurally similar compounds. The ligand compound was synthesized by the procedure described in the literature. It is noteworthy to mention that 2- (azidomethyl)cyclopropane-1,1-dicarboxylic acid presents the precursor for the synthesis of 2- (aminomethyl)cyclopropane-1,1-dicarboxylic acid, as an example of the constrained γ-amino dicarboxylic acids. The synthesis was achieved by the conversion of the ligand compound into the corresponding sodium dicarboxylate salt and subsequent treatment with [Pd(dien)Cl]Cl (pH maintained between 6-7). The IR and NMR spectra, as well as elemental analysis have confirmed that the Na[Pd(dien)(azmcpda)]. H2O species was formed and that coordination of the ligand compound to the metal ion was established through carboxylate oxygen donor atom.
钯(ii) - 2-(叠氮多甲基)环丙烷-1,1-二羧酸配合物的合成与表征
钯配合物具有广泛的生物活性(从抗肿瘤、病毒、疟疾、真菌到抗菌活性),这一发现鼓励了这一科学领域的进一步研究。本文以[Pd(dien)Cl]Cl和2-(叠氮多甲基)环丙烷-1,1-二羧酸(azmcpda)为配体,合成并表征了一种新型钯(II)配合物。[Pd(dien)Cl]Cl作为研究配位化学中取代反应的重要模型,以及对一些结构相似的化合物的生物活性有更深入的了解,因此选择Cl作为起始材料。该配体化合物按文献中描述的方法合成。值得注意的是,2-(叠氮多甲基)环丙烷-1,1-二羧酸是合成2-(氨甲基)环丙烷-1,1-二羧酸的前体,作为约束γ-氨基二羧酸的一个例子。通过将配体化合物转化为相应的二羧酸钠盐,然后用[Pd(dien)Cl]Cl (pH保持在6-7之间)处理来合成。红外和核磁共振光谱以及元素分析证实了Na[Pd(dien)(azmcpda)]。通过羧酸给氧原子与金属离子建立了配体化合物的配位关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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